Antifungal of modified neolignans from Mitrephora wangii Hu

• Main Authors: Saksri Sanyacharernkul, Sirinapa Nantapap, Kallaya Sangrueng, Narong Nuntasaen, Wilart Pompimon, Puttinan Meepowpan
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84977566665&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/55200
• Institution: Chiang Mai University

© 2016, The Korean Society for Applied Biological Chemistry. Chromatographic separation of leaves and twigs from M. wangii had led to the isolation of conocarpan (1) and 3′-methoxyconocarpan (2). These structures were assigned on the basis of spectroscopic methods. Compound 1 was modified by organic reactions and the modified compound 5 exhibited potent antifungal, Pyricularia oryzae. The method used poisoned food technique with mycelial growth inhibition for 14 days, 57 % (100 ppm). Compound 5 was stronger than mancozeb which the fungi toxicity drug used as a positive control.