Is salivary gland function altered in noninsulin-dependent diabetes mellitus and obesity-insulin resistance?
© 2016 Elsevier Ltd. All rights reserved. Salivary gland dysfunction in several systemic diseases has been shown to decrease the quality of life in patients. In non-insulin dependent diabetes mellitus (NIDDM), inadequate salivary gland function has been evidenced to closely associate with this abnor...
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th-cmuir.6653943832-552232018-09-05T03:10:00Z Is salivary gland function altered in noninsulin-dependent diabetes mellitus and obesity-insulin resistance? Jitjiroj Ittichaicharoen Nipon Chattipakorn Siriporn C. Chattipakorn Biochemistry, Genetics and Molecular Biology Dentistry Medicine © 2016 Elsevier Ltd. All rights reserved. Salivary gland dysfunction in several systemic diseases has been shown to decrease the quality of life in patients. In non-insulin dependent diabetes mellitus (NIDDM), inadequate salivary gland function has been evidenced to closely associate with this abnormal glycemic control condition. Although several studies demonstrated that NIDDM has a positive correlation with impaired salivary gland function, including decreased salivary flow rate, some studies demonstrated contradictory findings. Moreover, the changes of the salivary gland function in pre-diabetic stage known as insulin resistance are still unclear. The aim of this review is to comprehensively summarize the current evidence from in vitro, in vivo and clinical studies regarding the relationship between NIDDM and salivary gland function, as well as the correlation between obesity and salivary gland function. Consistent findings as well as controversial reports and the mechanistic insights regarding the effect of NIDDM and obesity-insulin resistance on salivary gland function are also presented and discussed. 2018-09-05T02:53:16Z 2018-09-05T02:53:16Z 2016-04-01 Journal 18791506 00039969 2-s2.0-84954449523 10.1016/j.archoralbio.2016.01.002 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84954449523&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/55223 |
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Biochemistry, Genetics and Molecular Biology Dentistry Medicine Jitjiroj Ittichaicharoen Nipon Chattipakorn Siriporn C. Chattipakorn Is salivary gland function altered in noninsulin-dependent diabetes mellitus and obesity-insulin resistance? |
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© 2016 Elsevier Ltd. All rights reserved. Salivary gland dysfunction in several systemic diseases has been shown to decrease the quality of life in patients. In non-insulin dependent diabetes mellitus (NIDDM), inadequate salivary gland function has been evidenced to closely associate with this abnormal glycemic control condition. Although several studies demonstrated that NIDDM has a positive correlation with impaired salivary gland function, including decreased salivary flow rate, some studies demonstrated contradictory findings. Moreover, the changes of the salivary gland function in pre-diabetic stage known as insulin resistance are still unclear. The aim of this review is to comprehensively summarize the current evidence from in vitro, in vivo and clinical studies regarding the relationship between NIDDM and salivary gland function, as well as the correlation between obesity and salivary gland function. Consistent findings as well as controversial reports and the mechanistic insights regarding the effect of NIDDM and obesity-insulin resistance on salivary gland function are also presented and discussed. |
format |
Journal |
author |
Jitjiroj Ittichaicharoen Nipon Chattipakorn Siriporn C. Chattipakorn |
author_facet |
Jitjiroj Ittichaicharoen Nipon Chattipakorn Siriporn C. Chattipakorn |
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Jitjiroj Ittichaicharoen |
title |
Is salivary gland function altered in noninsulin-dependent diabetes mellitus and obesity-insulin resistance? |
title_short |
Is salivary gland function altered in noninsulin-dependent diabetes mellitus and obesity-insulin resistance? |
title_full |
Is salivary gland function altered in noninsulin-dependent diabetes mellitus and obesity-insulin resistance? |
title_fullStr |
Is salivary gland function altered in noninsulin-dependent diabetes mellitus and obesity-insulin resistance? |
title_full_unstemmed |
Is salivary gland function altered in noninsulin-dependent diabetes mellitus and obesity-insulin resistance? |
title_sort |
is salivary gland function altered in noninsulin-dependent diabetes mellitus and obesity-insulin resistance? |
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2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84954449523&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/55223 |
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