Development and validation of an oligonucleotide ligation assay to detect lamivudine resistance in hepatitis B virus

• Main Authors: Ingrid A. Beck, Rachel Payant, Nicole Ngo-Giang-Huong, Woottichai Khamduang, Laddawan Laomanit, Gonzague Jourdain, Lisa M. Frenkel
• Format: Journal
• Published: 2018
• Subjects: Immunology and Microbiology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84962283790&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/55894
• Institution: Chiang Mai University

© 2016 Elsevier B.V. Treatment of chronic hepatitis B virus (HBV) infection with lamivudine-monotherapy rapidly selects mutant variants in a high proportion of individuals. Monitoring lamivudine resistance by consensus sequencing is costly and insensitive for detection of minority variants. An oligo...