Acute and chronic toxicities of Bacopa monnieri extract in Sprague-Dawley rats

© 2016 The Author(s). Background: Bacopa monnieri is a medicinal plant which has long been used in Ayurvedic medicines to augment brain function and to improve memory. The purpose of our study was to identify and evaluate possible toxic effects of B. monnieri extract in rats by assessing hematologic...

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Main Authors: Seewaboon Sireeratawong, Kanjana Jaijoy, Parirat Khonsung, Nirush Lertprasertsuk, Kornkanok Ingkaninan
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/56107
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-561072018-09-05T03:09:02Z Acute and chronic toxicities of Bacopa monnieri extract in Sprague-Dawley rats Seewaboon Sireeratawong Kanjana Jaijoy Parirat Khonsung Nirush Lertprasertsuk Kornkanok Ingkaninan Medicine © 2016 The Author(s). Background: Bacopa monnieri is a medicinal plant which has long been used in Ayurvedic medicines to augment brain function and to improve memory. The purpose of our study was to identify and evaluate possible toxic effects of B. monnieri extract in rats by assessing hematological, biochemical, and histopathological parameters. Methods: Acute oral toxicity of Bacopa monnieri extract was studied in female rats by giving a single orally administered dose at a level of 5,000 mg/kg. The rats were monitored for toxic signs for 14 days. In the chronic toxicity test, groups of both female and male rats were given daily oral doses of B. monnieri extract at dose levels of either 30, 60, 300 or 1,500 mg/kg for 270 days. The behavior and health of the animals was then monitored. At the end of the observation period, the body and organ weights of the rats in each group were measured. Blood was collected and necropsy was performed to evaluate their hematology, blood clinical chemistry, and microanatomy. Results: The acute toxicity test found no significant differences between the experimental and the control group rats. In the chronic toxicity test, animal behavior and health of the experimental groups were normal, just as in the control rats. All values of other parameters assessed remained within the normal range. Conclusion: A single oral administration of B. monnieri extract at the dose of 5,000 mg/kg did not cause any serious undesirable effects. B. monnieri extract at doses of 30, 60, 300 and 1,500 mg/kg given for 270 days did not produce any toxicity in rats. 2018-09-05T03:09:02Z 2018-09-05T03:09:02Z 2016-07-27 Journal 14726882 2-s2.0-84979248500 10.1186/s12906-016-1236-4 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84979248500&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/56107
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Seewaboon Sireeratawong
Kanjana Jaijoy
Parirat Khonsung
Nirush Lertprasertsuk
Kornkanok Ingkaninan
Acute and chronic toxicities of Bacopa monnieri extract in Sprague-Dawley rats
description © 2016 The Author(s). Background: Bacopa monnieri is a medicinal plant which has long been used in Ayurvedic medicines to augment brain function and to improve memory. The purpose of our study was to identify and evaluate possible toxic effects of B. monnieri extract in rats by assessing hematological, biochemical, and histopathological parameters. Methods: Acute oral toxicity of Bacopa monnieri extract was studied in female rats by giving a single orally administered dose at a level of 5,000 mg/kg. The rats were monitored for toxic signs for 14 days. In the chronic toxicity test, groups of both female and male rats were given daily oral doses of B. monnieri extract at dose levels of either 30, 60, 300 or 1,500 mg/kg for 270 days. The behavior and health of the animals was then monitored. At the end of the observation period, the body and organ weights of the rats in each group were measured. Blood was collected and necropsy was performed to evaluate their hematology, blood clinical chemistry, and microanatomy. Results: The acute toxicity test found no significant differences between the experimental and the control group rats. In the chronic toxicity test, animal behavior and health of the experimental groups were normal, just as in the control rats. All values of other parameters assessed remained within the normal range. Conclusion: A single oral administration of B. monnieri extract at the dose of 5,000 mg/kg did not cause any serious undesirable effects. B. monnieri extract at doses of 30, 60, 300 and 1,500 mg/kg given for 270 days did not produce any toxicity in rats.
format Journal
author Seewaboon Sireeratawong
Kanjana Jaijoy
Parirat Khonsung
Nirush Lertprasertsuk
Kornkanok Ingkaninan
author_facet Seewaboon Sireeratawong
Kanjana Jaijoy
Parirat Khonsung
Nirush Lertprasertsuk
Kornkanok Ingkaninan
author_sort Seewaboon Sireeratawong
title Acute and chronic toxicities of Bacopa monnieri extract in Sprague-Dawley rats
title_short Acute and chronic toxicities of Bacopa monnieri extract in Sprague-Dawley rats
title_full Acute and chronic toxicities of Bacopa monnieri extract in Sprague-Dawley rats
title_fullStr Acute and chronic toxicities of Bacopa monnieri extract in Sprague-Dawley rats
title_full_unstemmed Acute and chronic toxicities of Bacopa monnieri extract in Sprague-Dawley rats
title_sort acute and chronic toxicities of bacopa monnieri extract in sprague-dawley rats
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84979248500&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/56107
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