Vagus Nerve Stimulation Improves Cardiac Function by Preventing Mitochondrial Dysfunction in Obese-Insulin Resistant Rats
Long-term high-fat diet (HFD) consumption leads to not only obese-insulin resistance, but also impaired left ventricular (LV) function. Vagus nerve stimulation (VNS) has been shown to exert cardioprotection. However, its effects on the heart and metabolic parameters under obese-insulin resistant con...
Saved in:
Main Authors: | , , , , , , , |
---|---|
Format: | Journal |
Published: |
2018
|
Subjects: | |
Online Access: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84956654538&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/56373 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Chiang Mai University |
id |
th-cmuir.6653943832-56373 |
---|---|
record_format |
dspace |
spelling |
th-cmuir.6653943832-563732018-09-05T03:15:36Z Vagus Nerve Stimulation Improves Cardiac Function by Preventing Mitochondrial Dysfunction in Obese-Insulin Resistant Rats Bencharunan Samniang Krekwit Shinlapawittayatorn Titikorn Chunchai Wanpitak Pongkan Sirinart Kumfu Siriporn C. Chattipakorn Bruce H. Kenknight Nipon Chattipakorn Multidisciplinary Long-term high-fat diet (HFD) consumption leads to not only obese-insulin resistance, but also impaired left ventricular (LV) function. Vagus nerve stimulation (VNS) has been shown to exert cardioprotection. However, its effects on the heart and metabolic parameters under obese-insulin resistant condition is not known. We determined the effects of VNS on metabolic parameters, heart rate variability (HRV) and LV function in obese-insulin resistant rats. Male Wistar rats were fed with HFD for 12 weeks, and were randomly divided into sham and VNS groups. VNS was applied for the next 12 weeks. Echocardiography, blood pressure and HRV were examined. Blood samples were collected for metabolic parameters. At the end, the heart was removed for determination of apoptosis, inflammation, oxidative stress, and cardiac mitochondrial function. VNS for 12 weeks significantly decreased plasma insulin, HOMA index, total cholesterol, triglyceride, LDL and visceral fat. Serum adiponectin was significantly increased in the VNS group. VNS also significantly decreased blood pressure, improved HRV and LV function, decreased cardiac MDA, TNF-α and Bax levels, and improved cardiac mitochondrial function. VNS improves metabolic and hemodynamic parameters, and the LV function via its ability against apoptosis, inflammation and oxidative stress, and preserved cardiac mitochondrial function in obese-insulin resistant rats. 2018-09-05T03:15:36Z 2018-09-05T03:15:36Z 2016-02-01 Journal 20452322 2-s2.0-84956654538 10.1038/srep19749 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84956654538&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/56373 |
institution |
Chiang Mai University |
building |
Chiang Mai University Library |
country |
Thailand |
collection |
CMU Intellectual Repository |
topic |
Multidisciplinary |
spellingShingle |
Multidisciplinary Bencharunan Samniang Krekwit Shinlapawittayatorn Titikorn Chunchai Wanpitak Pongkan Sirinart Kumfu Siriporn C. Chattipakorn Bruce H. Kenknight Nipon Chattipakorn Vagus Nerve Stimulation Improves Cardiac Function by Preventing Mitochondrial Dysfunction in Obese-Insulin Resistant Rats |
description |
Long-term high-fat diet (HFD) consumption leads to not only obese-insulin resistance, but also impaired left ventricular (LV) function. Vagus nerve stimulation (VNS) has been shown to exert cardioprotection. However, its effects on the heart and metabolic parameters under obese-insulin resistant condition is not known. We determined the effects of VNS on metabolic parameters, heart rate variability (HRV) and LV function in obese-insulin resistant rats. Male Wistar rats were fed with HFD for 12 weeks, and were randomly divided into sham and VNS groups. VNS was applied for the next 12 weeks. Echocardiography, blood pressure and HRV were examined. Blood samples were collected for metabolic parameters. At the end, the heart was removed for determination of apoptosis, inflammation, oxidative stress, and cardiac mitochondrial function. VNS for 12 weeks significantly decreased plasma insulin, HOMA index, total cholesterol, triglyceride, LDL and visceral fat. Serum adiponectin was significantly increased in the VNS group. VNS also significantly decreased blood pressure, improved HRV and LV function, decreased cardiac MDA, TNF-α and Bax levels, and improved cardiac mitochondrial function. VNS improves metabolic and hemodynamic parameters, and the LV function via its ability against apoptosis, inflammation and oxidative stress, and preserved cardiac mitochondrial function in obese-insulin resistant rats. |
format |
Journal |
author |
Bencharunan Samniang Krekwit Shinlapawittayatorn Titikorn Chunchai Wanpitak Pongkan Sirinart Kumfu Siriporn C. Chattipakorn Bruce H. Kenknight Nipon Chattipakorn |
author_facet |
Bencharunan Samniang Krekwit Shinlapawittayatorn Titikorn Chunchai Wanpitak Pongkan Sirinart Kumfu Siriporn C. Chattipakorn Bruce H. Kenknight Nipon Chattipakorn |
author_sort |
Bencharunan Samniang |
title |
Vagus Nerve Stimulation Improves Cardiac Function by Preventing Mitochondrial Dysfunction in Obese-Insulin Resistant Rats |
title_short |
Vagus Nerve Stimulation Improves Cardiac Function by Preventing Mitochondrial Dysfunction in Obese-Insulin Resistant Rats |
title_full |
Vagus Nerve Stimulation Improves Cardiac Function by Preventing Mitochondrial Dysfunction in Obese-Insulin Resistant Rats |
title_fullStr |
Vagus Nerve Stimulation Improves Cardiac Function by Preventing Mitochondrial Dysfunction in Obese-Insulin Resistant Rats |
title_full_unstemmed |
Vagus Nerve Stimulation Improves Cardiac Function by Preventing Mitochondrial Dysfunction in Obese-Insulin Resistant Rats |
title_sort |
vagus nerve stimulation improves cardiac function by preventing mitochondrial dysfunction in obese-insulin resistant rats |
publishDate |
2018 |
url |
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84956654538&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/56373 |
_version_ |
1681424679826358272 |