Antioxidant, cytotoxic and á-glucosidase inhibitory activities of compounds isolated from the twig extracts of maclura fruticosa

• Main Authors: Isaraporn Polbuppha, Wisanu Maneerat, Tawanun Sripisut, Thunwadee Limtharakul, Sarot Cheenpracha, Stephen G. Pyne, Chatchai Muanprasat, Sawinee Seemakhan, Suparerk Borwornpinyo, Surat Laphookhieo
• Format: Journal
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85026481448&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/56620
• Institution: Chiang Mai University

The first phytochemical investigation of the twig extracts of Maclura fruticosa led to the isolation and identification of a new xanthone, maclurafruticosone (1), together with 14 known compounds (2-15). All compounds were elucidated using spectroscopic methods as well as through comparisons made with data reported in the literature. Some isolated compounds were evaluated for their antioxidant, α-glucosidase inhibitory and cytotoxic activities. Compound 4, 6 and 7 showed significant antioxidant activity against DPPH radicals with IC50values ranging from 7.45-V16.12 μM. Compound 4 also exhibited potent activity against ABTS.,h+scavenging activity with an IC50value of 0.55 iÓ 0.01 £gM which was better than positive control (ascorbic acid, IC502.35-0.17 μM). Compound 12 showed significant α-glucosidase inhibitory activity with an IC50value of 0.02-0.37 mM. Compounds 5, 6 and 12 showed weak cytotoxic activities against a colon cancer cell line with IC50values ranging from 22.35-47.62 μM.