The impact of genetic polymorphisms on CYP1A2 activity in humans: a systematic review and meta-analysis
© 2017 Macmillan Publishers Limited, part of Springer Nature A large interindividual variation in the activity of cytochrome P450 1A2 (CYP1A2) raises concern about therapeutic failure or toxicity when medical professionals prescribe drugs extensively metabolized by CYP1A2. To date, a number of studi...
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th-cmuir.6653943832-566532018-09-05T03:51:27Z The impact of genetic polymorphisms on CYP1A2 activity in humans: a systematic review and meta-analysis Nut Koonrungsesomboon Rapheephorn Khatsri Penwisa Wongchompoo Supanimit Teekachunhatean Biochemistry, Genetics and Molecular Biology Pharmacology, Toxicology and Pharmaceutics © 2017 Macmillan Publishers Limited, part of Springer Nature A large interindividual variation in the activity of cytochrome P450 1A2 (CYP1A2) raises concern about therapeutic failure or toxicity when medical professionals prescribe drugs extensively metabolized by CYP1A2. To date, a number of studies have assessed the association between genetic polymorphisms and CYP1A2 activity; however, there are controversies as to the functional importance of CYP1A2 polymorphisms on the metabolism of CYP1A2 substrates. This systematic review and meta-analysis assessed the effects of genetic polymorphisms on CYP1A2 activity, as measured by caffeine metabolism, in a total of 3570 individual subjects. Higher enzyme activity was observed among those who were homozygous or heterozygous for the −163C>A polymorphism (rs762551), when compared to the wild-type individuals (SMD = 0.40, 95%CI = 0.12–0.68, p = 0.005; SMD = 0.32, 95%CI = 0.11–0.54, p = 0.003, respectively) and this was more pronounced among smokers (SMD = 0.92, 95%CI = 0.27–1.57, p = 0.005; SMD = 0.56, 95%CI = 0.22–0.90, p = 0.001, respectively). For other CYP1A2 polymorphisms, altered caffeine metabolic ratios were not seen. Our results indicate the functional importance of −163C>A polymorphism on CYP1A2 inducibility in humans. 2018-09-05T03:28:29Z 2018-09-05T03:28:29Z 2017-12-27 Journal 14731150 1470269X 2-s2.0-85039172574 10.1038/s41397-017-0011-3 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85039172574&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/56653 |
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Biochemistry, Genetics and Molecular Biology Pharmacology, Toxicology and Pharmaceutics Nut Koonrungsesomboon Rapheephorn Khatsri Penwisa Wongchompoo Supanimit Teekachunhatean The impact of genetic polymorphisms on CYP1A2 activity in humans: a systematic review and meta-analysis |
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© 2017 Macmillan Publishers Limited, part of Springer Nature A large interindividual variation in the activity of cytochrome P450 1A2 (CYP1A2) raises concern about therapeutic failure or toxicity when medical professionals prescribe drugs extensively metabolized by CYP1A2. To date, a number of studies have assessed the association between genetic polymorphisms and CYP1A2 activity; however, there are controversies as to the functional importance of CYP1A2 polymorphisms on the metabolism of CYP1A2 substrates. This systematic review and meta-analysis assessed the effects of genetic polymorphisms on CYP1A2 activity, as measured by caffeine metabolism, in a total of 3570 individual subjects. Higher enzyme activity was observed among those who were homozygous or heterozygous for the −163C>A polymorphism (rs762551), when compared to the wild-type individuals (SMD = 0.40, 95%CI = 0.12–0.68, p = 0.005; SMD = 0.32, 95%CI = 0.11–0.54, p = 0.003, respectively) and this was more pronounced among smokers (SMD = 0.92, 95%CI = 0.27–1.57, p = 0.005; SMD = 0.56, 95%CI = 0.22–0.90, p = 0.001, respectively). For other CYP1A2 polymorphisms, altered caffeine metabolic ratios were not seen. Our results indicate the functional importance of −163C>A polymorphism on CYP1A2 inducibility in humans. |
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Journal |
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Nut Koonrungsesomboon Rapheephorn Khatsri Penwisa Wongchompoo Supanimit Teekachunhatean |
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Nut Koonrungsesomboon Rapheephorn Khatsri Penwisa Wongchompoo Supanimit Teekachunhatean |
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Nut Koonrungsesomboon |
title |
The impact of genetic polymorphisms on CYP1A2 activity in humans: a systematic review and meta-analysis |
title_short |
The impact of genetic polymorphisms on CYP1A2 activity in humans: a systematic review and meta-analysis |
title_full |
The impact of genetic polymorphisms on CYP1A2 activity in humans: a systematic review and meta-analysis |
title_fullStr |
The impact of genetic polymorphisms on CYP1A2 activity in humans: a systematic review and meta-analysis |
title_full_unstemmed |
The impact of genetic polymorphisms on CYP1A2 activity in humans: a systematic review and meta-analysis |
title_sort |
impact of genetic polymorphisms on cyp1a2 activity in humans: a systematic review and meta-analysis |
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2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85039172574&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/56653 |
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