Neuroprotection of agomelatine against cerebral ischemia/reperfusion injury through an antiapoptotic pathway in rat

• Main Authors: Wijitra Chumboatong, Sarinthorn Thummayot, Piyarat Govitrapong, Chainarong Tocharus, Jinatta Jittiwat, Jiraporn Tocharus
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Neuroscience
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85007524317&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/56839
• Institution: Chiang Mai University

© 2016 Elsevier Ltd Agomelatine is an agonist of the melatonergic MT1/MT2 receptors and an antagonist of the serotonergic 5-HT receptors. Its actions mimic melatonin in antioxidative and anti-inflammation. However, the protective mechanism of agomelatine in ischemic/reperfusion (I/R) injury has not...