Kuguacin J isolated from bitter melon leaves modulates paclitaxel sensitivity in drug-resistant human ovarian cancer cells

• Main Authors: Pornsiri Pitchakarn, Sonthaya Umsumarng, Sariya Mapoung, Pisamai Ting, Piya Temviriyanukul, Wanisa Punfa, Wilart Pompimon, Pornngarm Limtrakul
• Format: Journal
• Published: 2018
• Subjects: Chemistry; Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85021070299&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/56962
• Institution: Chiang Mai University

© 2017, The Japanese Society of Pharmacognosy and Springer Japan KK. We previously reported the multidrug resistance-reversing ability of kuguacin J (KJ) in cervical cancer cells via the inhibition of P-glycoprotein (P-gp) function. This study investigated whether KJ could promote cisplatin- and pac...