Mapping human genetic diversity in Asia

Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic an...

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Main Authors: Abdulla M.A., Ahmed I., Assawamakin A., Bhak J., Brahmachari S.K., Calacal G.C., Chaurasia A., Chen C.-H., Chen J., Chen Y.-T., Chu J., Cutiongco-de La Paz E.M.C., De Ungria M.C.A., Delfin F.C., Edo J., Fuchareon S., Ghang H., Gojobori T., Han J., Ho S.-F., Hoh B.P., Huang W., Inoko H., Jha P., Jinam T.A., Jin L., Jung J., Kangwanpong D., Kampuansai J., Kennedy G.C., Khurana P., Kim H.-L., Kim K., Kim S., Kim W.-Y., Kimm K., Kimura R., Koike T., Kulawonganunchai S., Kumar V., Lai P.S., Lee J.-Y., Lee S., Liu E.T., Majumder P.P., Mandapati K.K., Marzuki S., Mitchell W., Mukerji M., Naritomi K., Ngamphiw C., Niikawa N., Nishida N., Oh B., Oh S., Ohashi J., Oka A., Ong R., Padilla C.D., Palittapongarnpim P., Perdigon H.B., Phipps M.E., Png E., Sakaki Y., Salvador J.M., Sandraling Y., Scaria V., Seielstad M., Sidek M.R., Sinha A., Srikummool M., Sudoyo H., Sugano S., Suryadi H., Suzuki Y., Tabbada K.A., Tan A., Tokunaga K., Tongsima S., Villamor L.P., Wang E., Wang Y., Wang H., Wu J.-Y., Xiao H., Xu S., Yang J.O., Shugart Y.Y., Yoo H.-S., Yuan W., Zhao G., Zilfalil B.A.
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Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-72149083621&partnerID=40&md5=04cb919985605ffb7e35ea1d9196f124
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spelling th-cmuir.6653943832-57052014-08-30T03:23:21Z Mapping human genetic diversity in Asia Abdulla M.A. Ahmed I. Assawamakin A. Bhak J. Brahmachari S.K. Calacal G.C. Chaurasia A. Chen C.-H. Chen J. Chen Y.-T. Chu J. Cutiongco-de La Paz E.M.C. De Ungria M.C.A. Delfin F.C. Edo J. Fuchareon S. Ghang H. Gojobori T. Han J. Ho S.-F. Hoh B.P. Huang W. Inoko H. Jha P. Jinam T.A. Jin L. Jung J. Kangwanpong D. Kampuansai J. Kennedy G.C. Khurana P. Kim H.-L. Kim K. Kim S. Kim W.-Y. Kimm K. Kimura R. Koike T. Kulawonganunchai S. Kumar V. Lai P.S. Lee J.-Y. Lee S. Liu E.T. Majumder P.P. Mandapati K.K. Marzuki S. Mitchell W. Mukerji M. Naritomi K. Ngamphiw C. Niikawa N. Nishida N. Oh B. Oh S. Ohashi J. Oka A. Ong R. Padilla C.D. Palittapongarnpim P. Perdigon H.B. Phipps M.E. Png E. Sakaki Y. Salvador J.M. Sandraling Y. Scaria V. Seielstad M. Sidek M.R. Sinha A. Srikummool M. Sudoyo H. Sugano S. Suryadi H. Suzuki Y. Tabbada K.A. Tan A. Tokunaga K. Tongsima S. Villamor L.P. Wang E. Wang Y. Wang H. Wu J.-Y. Xiao H. Xu S. Yang J.O. Shugart Y.Y. Yoo H.-S. Yuan W. Zhao G. Zilfalil B.A. Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations. 2014-08-30T03:23:20Z 2014-08-30T03:23:20Z 2009 Article 00368075 10.1126/science.1177074 20007900 SCIEA http://www.scopus.com/inward/record.url?eid=2-s2.0-72149083621&partnerID=40&md5=04cb919985605ffb7e35ea1d9196f124 http://cmuir.cmu.ac.th/handle/6653943832/5705 English
institution Chiang Mai University
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description Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.
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author Abdulla M.A.
Ahmed I.
Assawamakin A.
Bhak J.
Brahmachari S.K.
Calacal G.C.
Chaurasia A.
Chen C.-H.
Chen J.
Chen Y.-T.
Chu J.
Cutiongco-de La Paz E.M.C.
De Ungria M.C.A.
Delfin F.C.
Edo J.
Fuchareon S.
Ghang H.
Gojobori T.
Han J.
Ho S.-F.
Hoh B.P.
Huang W.
Inoko H.
Jha P.
Jinam T.A.
Jin L.
Jung J.
Kangwanpong D.
Kampuansai J.
Kennedy G.C.
Khurana P.
Kim H.-L.
Kim K.
Kim S.
Kim W.-Y.
Kimm K.
Kimura R.
Koike T.
Kulawonganunchai S.
Kumar V.
Lai P.S.
Lee J.-Y.
Lee S.
Liu E.T.
Majumder P.P.
Mandapati K.K.
Marzuki S.
Mitchell W.
Mukerji M.
Naritomi K.
Ngamphiw C.
Niikawa N.
Nishida N.
Oh B.
Oh S.
Ohashi J.
Oka A.
Ong R.
Padilla C.D.
Palittapongarnpim P.
Perdigon H.B.
Phipps M.E.
Png E.
Sakaki Y.
Salvador J.M.
Sandraling Y.
Scaria V.
Seielstad M.
Sidek M.R.
Sinha A.
Srikummool M.
Sudoyo H.
Sugano S.
Suryadi H.
Suzuki Y.
Tabbada K.A.
Tan A.
Tokunaga K.
Tongsima S.
Villamor L.P.
Wang E.
Wang Y.
Wang H.
Wu J.-Y.
Xiao H.
Xu S.
Yang J.O.
Shugart Y.Y.
Yoo H.-S.
Yuan W.
Zhao G.
Zilfalil B.A.
spellingShingle Abdulla M.A.
Ahmed I.
Assawamakin A.
Bhak J.
Brahmachari S.K.
Calacal G.C.
Chaurasia A.
Chen C.-H.
Chen J.
Chen Y.-T.
Chu J.
Cutiongco-de La Paz E.M.C.
De Ungria M.C.A.
Delfin F.C.
Edo J.
Fuchareon S.
Ghang H.
Gojobori T.
Han J.
Ho S.-F.
Hoh B.P.
Huang W.
Inoko H.
Jha P.
Jinam T.A.
Jin L.
Jung J.
Kangwanpong D.
Kampuansai J.
Kennedy G.C.
Khurana P.
Kim H.-L.
Kim K.
Kim S.
Kim W.-Y.
Kimm K.
Kimura R.
Koike T.
Kulawonganunchai S.
Kumar V.
Lai P.S.
Lee J.-Y.
Lee S.
Liu E.T.
Majumder P.P.
Mandapati K.K.
Marzuki S.
Mitchell W.
Mukerji M.
Naritomi K.
Ngamphiw C.
Niikawa N.
Nishida N.
Oh B.
Oh S.
Ohashi J.
Oka A.
Ong R.
Padilla C.D.
Palittapongarnpim P.
Perdigon H.B.
Phipps M.E.
Png E.
Sakaki Y.
Salvador J.M.
Sandraling Y.
Scaria V.
Seielstad M.
Sidek M.R.
Sinha A.
Srikummool M.
Sudoyo H.
Sugano S.
Suryadi H.
Suzuki Y.
Tabbada K.A.
Tan A.
Tokunaga K.
Tongsima S.
Villamor L.P.
Wang E.
Wang Y.
Wang H.
Wu J.-Y.
Xiao H.
Xu S.
Yang J.O.
Shugart Y.Y.
Yoo H.-S.
Yuan W.
Zhao G.
Zilfalil B.A.
Mapping human genetic diversity in Asia
author_facet Abdulla M.A.
Ahmed I.
Assawamakin A.
Bhak J.
Brahmachari S.K.
Calacal G.C.
Chaurasia A.
Chen C.-H.
Chen J.
Chen Y.-T.
Chu J.
Cutiongco-de La Paz E.M.C.
De Ungria M.C.A.
Delfin F.C.
Edo J.
Fuchareon S.
Ghang H.
Gojobori T.
Han J.
Ho S.-F.
Hoh B.P.
Huang W.
Inoko H.
Jha P.
Jinam T.A.
Jin L.
Jung J.
Kangwanpong D.
Kampuansai J.
Kennedy G.C.
Khurana P.
Kim H.-L.
Kim K.
Kim S.
Kim W.-Y.
Kimm K.
Kimura R.
Koike T.
Kulawonganunchai S.
Kumar V.
Lai P.S.
Lee J.-Y.
Lee S.
Liu E.T.
Majumder P.P.
Mandapati K.K.
Marzuki S.
Mitchell W.
Mukerji M.
Naritomi K.
Ngamphiw C.
Niikawa N.
Nishida N.
Oh B.
Oh S.
Ohashi J.
Oka A.
Ong R.
Padilla C.D.
Palittapongarnpim P.
Perdigon H.B.
Phipps M.E.
Png E.
Sakaki Y.
Salvador J.M.
Sandraling Y.
Scaria V.
Seielstad M.
Sidek M.R.
Sinha A.
Srikummool M.
Sudoyo H.
Sugano S.
Suryadi H.
Suzuki Y.
Tabbada K.A.
Tan A.
Tokunaga K.
Tongsima S.
Villamor L.P.
Wang E.
Wang Y.
Wang H.
Wu J.-Y.
Xiao H.
Xu S.
Yang J.O.
Shugart Y.Y.
Yoo H.-S.
Yuan W.
Zhao G.
Zilfalil B.A.
author_sort Abdulla M.A.
title Mapping human genetic diversity in Asia
title_short Mapping human genetic diversity in Asia
title_full Mapping human genetic diversity in Asia
title_fullStr Mapping human genetic diversity in Asia
title_full_unstemmed Mapping human genetic diversity in Asia
title_sort mapping human genetic diversity in asia
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-72149083621&partnerID=40&md5=04cb919985605ffb7e35ea1d9196f124
http://cmuir.cmu.ac.th/handle/6653943832/5705
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