Comparison of hepatitis b virus infection in HIV-infected and HIV-uninfected participants enrolled in a multinational clinical trial: HPTN 052
© 2017 Wolters Kluwer Health, Inc. All rights reserved. Objective: Data comparing hepatitis B virus (HBV) infection in HIV-infected [HIV(+)], and HIV-uninfected [HIV(2)] individuals recruited into the same study are limited. HBV infection status and chronic hepatitis B (cHB) were characterized in a...
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th-cmuir.6653943832-578392018-09-05T03:50:44Z Comparison of hepatitis b virus infection in HIV-infected and HIV-uninfected participants enrolled in a multinational clinical trial: HPTN 052 Amy E. Greer San San Ou Ethan Wilson Estelle Piwowar-Manning Michael S. Forman Marybeth McCauley Theresa Gamble Cholticha Ruangyuttikarn Mina C. Hosseinipour Nagalingeswaran Kumarasamy Mulinda Nyirenda Beatriz Grinsztejn Jose Henrique Pilotto Natthapol Kosashunhanan Marineide Gonçalves De Melo Joseph Makhema Victor Akelo Ravindre Panchia Sharlaa Badal-Faesen Ying Q. Chen Myron S. Cohen Susan H. Eshleman Chloe L. Thio Alexandra Valsamakis Medicine © 2017 Wolters Kluwer Health, Inc. All rights reserved. Objective: Data comparing hepatitis B virus (HBV) infection in HIV-infected [HIV(+)], and HIV-uninfected [HIV(2)] individuals recruited into the same study are limited. HBV infection status and chronic hepatitis B (cHB) were characterized in a multinational clinical trial: HIV Prevention Trials Network (HPTN 052). Method: HBV infection status at enrollment was compared between HIV(+) (N = 1241) and HIV(-) (N = 1232) from 7 HBV-endemic countries. Hepatitis B e antigen and plasma HBV DNA were determined in cHB. Median CD4, median plasma HIV RNA, and prevalence of transaminase elevation were compared in HIV(+) with and without cHB. Significance was assessed with x2Fisher exact and median tests. Results: Among all participants, 33.6% had HBV exposure without cHB (8.9% isolated HBV core antibody, "HBcAb"; 24.7% HBcAb and anti-HB surface antibody positive, "recovered"), 4.3% had cHB, 8.9% were vaccinated, and 53.5% were uninfected. Data were similar among HIV(+) and HIV(2) except for isolated HBcAb, which was more prevalent in HIV(+) than HIV(2) [10.1% vs. 7.7%, P = 0.046]. Median HBV DNA trended higher in HIV(+) than in HIV(2). In HIV (+) with cHB versus those without cHB, transaminase elevations were more prevalent (alanine aminotransferase # grade 2, 12% vs. 5.2%, P = 0.037; aspartate aminotransferase # grade 2, 26% vs. 6.0%, P, 0.001), CD4 trended lower, and HIV RNA was similar. Conclusions: HBV infection status did not differ by HIV infection status. HIV co-infection was associated with isolated HBcAb and a trend of increased HBV DNA. In HIV, cHB was associated with mild transaminase elevations and a trend toward lower CD4. 2018-09-05T03:50:44Z 2018-09-05T03:50:44Z 2017-01-01 Journal 10779450 15254135 2-s2.0-85026363946 10.1097/QAI.0000000000001511 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85026363946&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/57839 |
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Medicine Amy E. Greer San San Ou Ethan Wilson Estelle Piwowar-Manning Michael S. Forman Marybeth McCauley Theresa Gamble Cholticha Ruangyuttikarn Mina C. Hosseinipour Nagalingeswaran Kumarasamy Mulinda Nyirenda Beatriz Grinsztejn Jose Henrique Pilotto Natthapol Kosashunhanan Marineide Gonçalves De Melo Joseph Makhema Victor Akelo Ravindre Panchia Sharlaa Badal-Faesen Ying Q. Chen Myron S. Cohen Susan H. Eshleman Chloe L. Thio Alexandra Valsamakis Comparison of hepatitis b virus infection in HIV-infected and HIV-uninfected participants enrolled in a multinational clinical trial: HPTN 052 |
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© 2017 Wolters Kluwer Health, Inc. All rights reserved. Objective: Data comparing hepatitis B virus (HBV) infection in HIV-infected [HIV(+)], and HIV-uninfected [HIV(2)] individuals recruited into the same study are limited. HBV infection status and chronic hepatitis B (cHB) were characterized in a multinational clinical trial: HIV Prevention Trials Network (HPTN 052). Method: HBV infection status at enrollment was compared between HIV(+) (N = 1241) and HIV(-) (N = 1232) from 7 HBV-endemic countries. Hepatitis B e antigen and plasma HBV DNA were determined in cHB. Median CD4, median plasma HIV RNA, and prevalence of transaminase elevation were compared in HIV(+) with and without cHB. Significance was assessed with x2Fisher exact and median tests. Results: Among all participants, 33.6% had HBV exposure without cHB (8.9% isolated HBV core antibody, "HBcAb"; 24.7% HBcAb and anti-HB surface antibody positive, "recovered"), 4.3% had cHB, 8.9% were vaccinated, and 53.5% were uninfected. Data were similar among HIV(+) and HIV(2) except for isolated HBcAb, which was more prevalent in HIV(+) than HIV(2) [10.1% vs. 7.7%, P = 0.046]. Median HBV DNA trended higher in HIV(+) than in HIV(2). In HIV (+) with cHB versus those without cHB, transaminase elevations were more prevalent (alanine aminotransferase # grade 2, 12% vs. 5.2%, P = 0.037; aspartate aminotransferase # grade 2, 26% vs. 6.0%, P, 0.001), CD4 trended lower, and HIV RNA was similar. Conclusions: HBV infection status did not differ by HIV infection status. HIV co-infection was associated with isolated HBcAb and a trend of increased HBV DNA. In HIV, cHB was associated with mild transaminase elevations and a trend toward lower CD4. |
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Amy E. Greer San San Ou Ethan Wilson Estelle Piwowar-Manning Michael S. Forman Marybeth McCauley Theresa Gamble Cholticha Ruangyuttikarn Mina C. Hosseinipour Nagalingeswaran Kumarasamy Mulinda Nyirenda Beatriz Grinsztejn Jose Henrique Pilotto Natthapol Kosashunhanan Marineide Gonçalves De Melo Joseph Makhema Victor Akelo Ravindre Panchia Sharlaa Badal-Faesen Ying Q. Chen Myron S. Cohen Susan H. Eshleman Chloe L. Thio Alexandra Valsamakis |
author_facet |
Amy E. Greer San San Ou Ethan Wilson Estelle Piwowar-Manning Michael S. Forman Marybeth McCauley Theresa Gamble Cholticha Ruangyuttikarn Mina C. Hosseinipour Nagalingeswaran Kumarasamy Mulinda Nyirenda Beatriz Grinsztejn Jose Henrique Pilotto Natthapol Kosashunhanan Marineide Gonçalves De Melo Joseph Makhema Victor Akelo Ravindre Panchia Sharlaa Badal-Faesen Ying Q. Chen Myron S. Cohen Susan H. Eshleman Chloe L. Thio Alexandra Valsamakis |
author_sort |
Amy E. Greer |
title |
Comparison of hepatitis b virus infection in HIV-infected and HIV-uninfected participants enrolled in a multinational clinical trial: HPTN 052 |
title_short |
Comparison of hepatitis b virus infection in HIV-infected and HIV-uninfected participants enrolled in a multinational clinical trial: HPTN 052 |
title_full |
Comparison of hepatitis b virus infection in HIV-infected and HIV-uninfected participants enrolled in a multinational clinical trial: HPTN 052 |
title_fullStr |
Comparison of hepatitis b virus infection in HIV-infected and HIV-uninfected participants enrolled in a multinational clinical trial: HPTN 052 |
title_full_unstemmed |
Comparison of hepatitis b virus infection in HIV-infected and HIV-uninfected participants enrolled in a multinational clinical trial: HPTN 052 |
title_sort |
comparison of hepatitis b virus infection in hiv-infected and hiv-uninfected participants enrolled in a multinational clinical trial: hptn 052 |
publishDate |
2018 |
url |
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85026363946&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/57839 |
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1681424953318047744 |