The additive effects of atorvastatin and insulin on renal function and renal organic anion transporter 3 function in diabetic rats

© 2017 The Author(s). Hyperglycemia-induced oxidative stress is usually found in diabetic condition. 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase inhibitors, statins, are widely used as cholesterol-lowering medication with several "pleiotropic" effects in diabetic patients. Th...

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Main Authors: Laongdao Thongnak, Anchalee Pongchaidecha, Krit Jaikumkao, Varanuj Chatsudthipong, Nipon Chattipakorn, Anusorn Lungkaphin
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/57960
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spelling th-cmuir.6653943832-579602018-09-05T03:55:34Z The additive effects of atorvastatin and insulin on renal function and renal organic anion transporter 3 function in diabetic rats Laongdao Thongnak Anchalee Pongchaidecha Krit Jaikumkao Varanuj Chatsudthipong Nipon Chattipakorn Anusorn Lungkaphin Multidisciplinary © 2017 The Author(s). Hyperglycemia-induced oxidative stress is usually found in diabetic condition. 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase inhibitors, statins, are widely used as cholesterol-lowering medication with several "pleiotropic" effects in diabetic patients. This study aims to evaluate whether the protective effects of atorvastatin and insulin on renal function and renal organic anion transporter 3 (Oat3) function involve the modulation of oxidative stress and pancreatic function in type 1 diabetic rats. Type 1 diabetes was induced by intraperitoneal injection of streptozotocin (50 mg/kg BW). Atorvastatin and insulin as single or combined treatment were given for 4 weeks after diabetic condition had been confirmed. Diabetic rats demonstrated renal function and renal Oat3 function impairment with an increased MDA level and decreased SOD protein expression concomitant with stimulation of renal Nrf2 and HO-1 protein expression. Insulin plus atorvastatin (combined) treatment effectively restored renal function as well as renal Oat3 function which correlated with the decrease in hyperglycemia and oxidative stress. Moreover, pancreatic inflammation and apoptosis in diabetic rats were ameliorated by the combined drugs treatment. Therefore, atorvastatin plus insulin seems to exert the additive effect in improving renal functionby alleviating hyperglycemiaand the modulation of oxidative stress, inflammation and apoptosis. 2018-09-05T03:55:34Z 2018-09-05T03:55:34Z 2017-12-01 Journal 20452322 2-s2.0-85044743396 10.1038/s41598-017-13206-5 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85044743396&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/57960
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Multidisciplinary
spellingShingle Multidisciplinary
Laongdao Thongnak
Anchalee Pongchaidecha
Krit Jaikumkao
Varanuj Chatsudthipong
Nipon Chattipakorn
Anusorn Lungkaphin
The additive effects of atorvastatin and insulin on renal function and renal organic anion transporter 3 function in diabetic rats
description © 2017 The Author(s). Hyperglycemia-induced oxidative stress is usually found in diabetic condition. 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase inhibitors, statins, are widely used as cholesterol-lowering medication with several "pleiotropic" effects in diabetic patients. This study aims to evaluate whether the protective effects of atorvastatin and insulin on renal function and renal organic anion transporter 3 (Oat3) function involve the modulation of oxidative stress and pancreatic function in type 1 diabetic rats. Type 1 diabetes was induced by intraperitoneal injection of streptozotocin (50 mg/kg BW). Atorvastatin and insulin as single or combined treatment were given for 4 weeks after diabetic condition had been confirmed. Diabetic rats demonstrated renal function and renal Oat3 function impairment with an increased MDA level and decreased SOD protein expression concomitant with stimulation of renal Nrf2 and HO-1 protein expression. Insulin plus atorvastatin (combined) treatment effectively restored renal function as well as renal Oat3 function which correlated with the decrease in hyperglycemia and oxidative stress. Moreover, pancreatic inflammation and apoptosis in diabetic rats were ameliorated by the combined drugs treatment. Therefore, atorvastatin plus insulin seems to exert the additive effect in improving renal functionby alleviating hyperglycemiaand the modulation of oxidative stress, inflammation and apoptosis.
format Journal
author Laongdao Thongnak
Anchalee Pongchaidecha
Krit Jaikumkao
Varanuj Chatsudthipong
Nipon Chattipakorn
Anusorn Lungkaphin
author_facet Laongdao Thongnak
Anchalee Pongchaidecha
Krit Jaikumkao
Varanuj Chatsudthipong
Nipon Chattipakorn
Anusorn Lungkaphin
author_sort Laongdao Thongnak
title The additive effects of atorvastatin and insulin on renal function and renal organic anion transporter 3 function in diabetic rats
title_short The additive effects of atorvastatin and insulin on renal function and renal organic anion transporter 3 function in diabetic rats
title_full The additive effects of atorvastatin and insulin on renal function and renal organic anion transporter 3 function in diabetic rats
title_fullStr The additive effects of atorvastatin and insulin on renal function and renal organic anion transporter 3 function in diabetic rats
title_full_unstemmed The additive effects of atorvastatin and insulin on renal function and renal organic anion transporter 3 function in diabetic rats
title_sort additive effects of atorvastatin and insulin on renal function and renal organic anion transporter 3 function in diabetic rats
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85044743396&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/57960
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