A comprehensive ethnic-based analysis of alpha thalassaemia allelle frequency in northern Thailand article

© 2017 The Author(s). Alpha (α)-thalassaemia is one of the most prevalent hereditary blood disorders, commonly affecting Southeast Asian people, with the highest incidence (30-40%) being seen in northern Thailand. However, this high incidence was estimated without consideration of the variations bet...

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Main Authors: Mattapong Kulaphisit, Jatupol Kampuansai, Kamonlak Leecharoenkiat, Methi Wathikthinnakon, Daoroong Kangwanpong, Thongperm Munkongdee, Saovaros Svasti, Suthat Fucharoen, Duncan R. Smith, Pathrapol Lithanatudom
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Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/57962
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spelling th-cmuir.6653943832-579622018-09-05T03:55:35Z A comprehensive ethnic-based analysis of alpha thalassaemia allelle frequency in northern Thailand article Mattapong Kulaphisit Jatupol Kampuansai Kamonlak Leecharoenkiat Methi Wathikthinnakon Daoroong Kangwanpong Thongperm Munkongdee Saovaros Svasti Suthat Fucharoen Duncan R. Smith Pathrapol Lithanatudom Multidisciplinary © 2017 The Author(s). Alpha (α)-thalassaemia is one of the most prevalent hereditary blood disorders, commonly affecting Southeast Asian people, with the highest incidence (30-40%) being seen in northern Thailand. However, this high incidence was estimated without consideration of the variations between ethnic populations and the geographical location of the populations. To address this issue, a total of 688 samples from 13 different northern Thai ethnic groups (30 villages) categorized into three linguistic groups were genotyped for deletional alpha-thalassaemia (-α3.7,-α4.2,-SEAand-THAI) and/or non-deletional alpha-thalassaemiaαCSand αPS) via multiplex gap-PCR and dot-blot hybridization, respectively. Alpha+(-α3.7,-α4.2, αCSand αPS) and alpha°-thalassaemia (-SEAand-THAI) allele frequencies (with 95% Confidence Interval) were the highest in the Sino-Tibetan group [0.13 (0.08-0.18)] and the Tai-Kadai group [0.03 (0.02-0.05)], respectively. With regards to ethnicity, the varying allele frequency of α+and α°-thalassaemia amongst a variety of ethnicgroups was observed. The highest α+-thalassaemia allele frequency wasfound in the Paluang [0.21 (0.10-0.37)] while α°-thalassaemia allele frequency was the highest in the Yuan [0.04 (0.01-0.10)]. These detailed results of alpha thalassaemia allele frequency and genetic diversity amongst the northern Thai ethnic groups demonstrate the need for ethnicity based thalassaemia prevention programs. 2018-09-05T03:55:35Z 2018-09-05T03:55:35Z 2017-12-01 Journal 20452322 2-s2.0-85021903308 10.1038/s41598-017-04957-2 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85021903308&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/57962
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Multidisciplinary
spellingShingle Multidisciplinary
Mattapong Kulaphisit
Jatupol Kampuansai
Kamonlak Leecharoenkiat
Methi Wathikthinnakon
Daoroong Kangwanpong
Thongperm Munkongdee
Saovaros Svasti
Suthat Fucharoen
Duncan R. Smith
Pathrapol Lithanatudom
A comprehensive ethnic-based analysis of alpha thalassaemia allelle frequency in northern Thailand article
description © 2017 The Author(s). Alpha (α)-thalassaemia is one of the most prevalent hereditary blood disorders, commonly affecting Southeast Asian people, with the highest incidence (30-40%) being seen in northern Thailand. However, this high incidence was estimated without consideration of the variations between ethnic populations and the geographical location of the populations. To address this issue, a total of 688 samples from 13 different northern Thai ethnic groups (30 villages) categorized into three linguistic groups were genotyped for deletional alpha-thalassaemia (-α3.7,-α4.2,-SEAand-THAI) and/or non-deletional alpha-thalassaemiaαCSand αPS) via multiplex gap-PCR and dot-blot hybridization, respectively. Alpha+(-α3.7,-α4.2, αCSand αPS) and alpha°-thalassaemia (-SEAand-THAI) allele frequencies (with 95% Confidence Interval) were the highest in the Sino-Tibetan group [0.13 (0.08-0.18)] and the Tai-Kadai group [0.03 (0.02-0.05)], respectively. With regards to ethnicity, the varying allele frequency of α+and α°-thalassaemia amongst a variety of ethnicgroups was observed. The highest α+-thalassaemia allele frequency wasfound in the Paluang [0.21 (0.10-0.37)] while α°-thalassaemia allele frequency was the highest in the Yuan [0.04 (0.01-0.10)]. These detailed results of alpha thalassaemia allele frequency and genetic diversity amongst the northern Thai ethnic groups demonstrate the need for ethnicity based thalassaemia prevention programs.
format Journal
author Mattapong Kulaphisit
Jatupol Kampuansai
Kamonlak Leecharoenkiat
Methi Wathikthinnakon
Daoroong Kangwanpong
Thongperm Munkongdee
Saovaros Svasti
Suthat Fucharoen
Duncan R. Smith
Pathrapol Lithanatudom
author_facet Mattapong Kulaphisit
Jatupol Kampuansai
Kamonlak Leecharoenkiat
Methi Wathikthinnakon
Daoroong Kangwanpong
Thongperm Munkongdee
Saovaros Svasti
Suthat Fucharoen
Duncan R. Smith
Pathrapol Lithanatudom
author_sort Mattapong Kulaphisit
title A comprehensive ethnic-based analysis of alpha thalassaemia allelle frequency in northern Thailand article
title_short A comprehensive ethnic-based analysis of alpha thalassaemia allelle frequency in northern Thailand article
title_full A comprehensive ethnic-based analysis of alpha thalassaemia allelle frequency in northern Thailand article
title_fullStr A comprehensive ethnic-based analysis of alpha thalassaemia allelle frequency in northern Thailand article
title_full_unstemmed A comprehensive ethnic-based analysis of alpha thalassaemia allelle frequency in northern Thailand article
title_sort comprehensive ethnic-based analysis of alpha thalassaemia allelle frequency in northern thailand article
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85021903308&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/57962
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