Sesamin suppresses LPS-induced microglial activation via regulation of TLR4 expression

• Main Authors: Sasimol Udomruk, Chayanut Kaewmool, Peraphan Pothacharoen, Thanyaluck Phitak, Prachya Kongtawelert
• Format: Journal
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Medicine; Nursing
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85051637712&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/58003
• Institution: Chiang Mai University

© 2018 Elsevier Ltd Sesamin, one of the most abundant lignans in sesame seeds and oils, is well known for neuroprotective activity. However, its effects on toll-like-receptor 4 (TLR4), the key innate immune receptor implicated in microglia activation and neuroinflammation has not been reported. Our...