Inhibition of IL-10 and TGF-β receptors on dendritic cells enhances activation of effector T-cells to kill cholangiocarcinoma cells

• Main Authors: Chutamas Thepmalee, Aussara Panya, Mutita Junking, Thaweesak Chieochansin, Pa thai Yenchitsomanus
• Format: Journal
• Published: 2018
• Subjects: Immunology and Microbiology; Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85042237268&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/58765
• Institution: Chiang Mai University

© 2018, © 2018 Siriraj Hospital, Mahidol University. Tumor escapes host immune responses by producing immunosuppressive cytokines, such as IL-10 and TGF-β, secreted into the tumor microenvironment. These cytokines play important roles in the suppression of dendritic cell (DC) function, leading to de...