Decreased Microglial Activation Through Gut-brain Axis by Prebiotics, Probiotics, or Synbiotics Effectively Restored Cognitive Function in Obese-insulin Resistant Rats

• Main Authors: Titikorn Chunchai, Wannipa Thunapong, Sakawdaurn Yasom, Keerati Wanchai, Sathima Eaimworawuthikul, Gabrielle Metzler, Anusorn Lungkaphin, Anchalee Pongchaidecha, Sasithorn Sirilun, Chaiyavat Chaiyasut, Wasana Pratchayasakul, Parameth Thiennimitr, Nipon Chattipakorn, Siriporn C. Chattipakorn
• Format: Journal
• Published: 2018
• Subjects: Immunology and Microbiology; Neuroscience
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85040343815&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/58770
• Institution: Chiang Mai University

© 2018 The Author(s). Background: Chronic high-fat diet (HFD) consumption caused not only obese-insulin resistance, but also cognitive decline and microglial hyperactivity. Modified gut microbiota by prebiotics and probiotics improved obese-insulin resistance. However, the effects of prebiotics, pro...