A Mechanism-Based Population Pharmacokinetic Analysis Assessing the Feasibility of Efavirenz Dose Reduction to 400 mg in Pregnant Women

• Main Authors: Stein Schalkwijk, Rob Ter Heine, Angela C. Colbers, Alwin D.R. Huitema, Paolo Denti, Kelly E. Dooley, Edmund Capparelli, Brookie M. Best, Tim R. Cressey, Rick Greupink, Frans G.M. Russel, Mark Mirochnick, David M. Burger
• Format: Journal
• Published: 2018
• Subjects: Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85043397210&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/58961
• Institution: Chiang Mai University

© 2018 The Author(s) Background: Reducing the dose of efavirenz can improve safety, reduce costs, and increase access for patients with HIV infection. According to the World Health Organization, a similar dosing strategy for all patient populations is desirable for universal roll-out; however, it re...