Antitubercular cassane furanoditerpenoids from the roots of Caesalpinia pulcherrima
Activity-guided fractionation of a root extract of Caesalpinia pulcherrima led to the isolation of two cassane-furanoditerpenoids, 6β-benzoyl-7β -hydroxyvouacapen-5α-ol (1) and 6β-cinnamoyl-7β -hydroxyvouacapen-5α-ol (2). Compound 2 showed strong antitubercular activity with a minimum inhibitory con...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2014
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| Online Access: | http://www.scopus.com/inward/record.url?eid=2-s2.0-0141482073&partnerID=40&md5=85c00b21a944ebd06f509ee4781775aa http://www.ncbi.nlm.nih.gov/pubmed/14531033 http://cmuir.cmu.ac.th/handle/6653943832/5987 |
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| Institution: | Chiang Mai University |
| Language: | English |
| Summary: | Activity-guided fractionation of a root extract of Caesalpinia pulcherrima led to the isolation of two cassane-furanoditerpenoids, 6β-benzoyl-7β -hydroxyvouacapen-5α-ol (1) and 6β-cinnamoyl-7β -hydroxyvouacapen-5α-ol (2). Compound 2 showed strong antitubercular activity with a minimum inhibitory concentration (MIC) of 6.25 μg/mL, whereas the benzoyl analogue (1) was less active (MIC 25 μg/mL). Both compounds expressed moderate cytotoxic activity towards KB (human oral carcinonoid cancer), BC (human breast cancer) and NCI-H187 (small cell lung cancer) cell lines. |
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