Antitubercular cassane furanoditerpenoids from the roots of Caesalpinia pulcherrima
Activity-guided fractionation of a root extract of Caesalpinia pulcherrima led to the isolation of two cassane-furanoditerpenoids, 6β-benzoyl-7β -hydroxyvouacapen-5α-ol (1) and 6β-cinnamoyl-7β -hydroxyvouacapen-5α-ol (2). Compound 2 showed strong antitubercular activity with a minimum inhibitory con...
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2014
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th-cmuir.6653943832-59872014-08-30T03:23:42Z Antitubercular cassane furanoditerpenoids from the roots of Caesalpinia pulcherrima Promsawan N. Kittakoop P. Boonphong S. Nongkunsarn P. Activity-guided fractionation of a root extract of Caesalpinia pulcherrima led to the isolation of two cassane-furanoditerpenoids, 6β-benzoyl-7β -hydroxyvouacapen-5α-ol (1) and 6β-cinnamoyl-7β -hydroxyvouacapen-5α-ol (2). Compound 2 showed strong antitubercular activity with a minimum inhibitory concentration (MIC) of 6.25 μg/mL, whereas the benzoyl analogue (1) was less active (MIC 25 μg/mL). Both compounds expressed moderate cytotoxic activity towards KB (human oral carcinonoid cancer), BC (human breast cancer) and NCI-H187 (small cell lung cancer) cell lines. 2014-08-30T03:23:42Z 2014-08-30T03:23:42Z 2003 Article 00320943 10.1055/s-2003-42782 14531033 PLMEA http://www.scopus.com/inward/record.url?eid=2-s2.0-0141482073&partnerID=40&md5=85c00b21a944ebd06f509ee4781775aa http://www.ncbi.nlm.nih.gov/pubmed/14531033 http://cmuir.cmu.ac.th/handle/6653943832/5987 English |
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English |
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Activity-guided fractionation of a root extract of Caesalpinia pulcherrima led to the isolation of two cassane-furanoditerpenoids, 6β-benzoyl-7β -hydroxyvouacapen-5α-ol (1) and 6β-cinnamoyl-7β -hydroxyvouacapen-5α-ol (2). Compound 2 showed strong antitubercular activity with a minimum inhibitory concentration (MIC) of 6.25 μg/mL, whereas the benzoyl analogue (1) was less active (MIC 25 μg/mL). Both compounds expressed moderate cytotoxic activity towards KB (human oral carcinonoid cancer), BC (human breast cancer) and NCI-H187 (small cell lung cancer) cell lines. |
| format |
Article |
| author |
Promsawan N. Kittakoop P. Boonphong S. Nongkunsarn P. |
| spellingShingle |
Promsawan N. Kittakoop P. Boonphong S. Nongkunsarn P. Antitubercular cassane furanoditerpenoids from the roots of Caesalpinia pulcherrima |
| author_facet |
Promsawan N. Kittakoop P. Boonphong S. Nongkunsarn P. |
| author_sort |
Promsawan N. |
| title |
Antitubercular cassane furanoditerpenoids from the roots of Caesalpinia pulcherrima |
| title_short |
Antitubercular cassane furanoditerpenoids from the roots of Caesalpinia pulcherrima |
| title_full |
Antitubercular cassane furanoditerpenoids from the roots of Caesalpinia pulcherrima |
| title_fullStr |
Antitubercular cassane furanoditerpenoids from the roots of Caesalpinia pulcherrima |
| title_full_unstemmed |
Antitubercular cassane furanoditerpenoids from the roots of Caesalpinia pulcherrima |
| title_sort |
antitubercular cassane furanoditerpenoids from the roots of caesalpinia pulcherrima |
| publishDate |
2014 |
| url |
http://www.scopus.com/inward/record.url?eid=2-s2.0-0141482073&partnerID=40&md5=85c00b21a944ebd06f509ee4781775aa http://www.ncbi.nlm.nih.gov/pubmed/14531033 http://cmuir.cmu.ac.th/handle/6653943832/5987 |
| _version_ |
1681420528988979200 |