Efficacy of curcuminoids in alleviation of iron overload and lipid peroxidation in thalassemic mice

• Main Authors: C. Thephinlap, C. Phisalaphong, S. Fucharoen, J. B. Porter, S. Srichairatanakool
• Format: Journal
• Published: 2018
• Subjects: Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=70349142708&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/59923
• Institution: Chiang Mai University

Non-transferrin bound iron (NTBI) is detectable in plasma of β-thalassemia patients and participates in free-radical formation and oxidative tissue damage. Desferrioxamine (DFO), deferiprone (DFP) and deferasirox (DFX) are iron chelators used for treatment of iron overload; however they may cause ad...