Molecular dynamic simulations analysis of ritronavir and lopinavir as SARS-CoV 3CL^proinhibitors

• Main Authors: Veena Nukoolkarn, Vannajan Sanghiran Lee, Maturos Malaisree, Ornjira Aruksakulwong, Supot Hannongbua
• Format: Journal
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Mathematics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=52149096469&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/60042
• Institution: Chiang Mai University

Since the emergence of the severe acute respiratory syndrome (SARS) to date, neither an effective antiviral drug nor a vaccine against SARS is available. However, it was found that a mixture of two HIV-1 proteinase inhibitors, lopinavir and ritonavir, exhibited some signs of effectiveness against th...