Molecular dynamic simulations analysis of ritronavir and lopinavir as SARS-CoV 3CL^proinhibitors

• Main Authors: Veena Nukoolkarn, Vannajan Sanghiran Lee, Maturos Malaisree, Ornjira Aruksakulwong, Supot Hannongbua
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Mathematics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/18685

Since the emergence of the severe acute respiratory syndrome (SARS) to date, neither an effective antiviral drug nor a vaccine against SARS is available. However, it was found that a mixture of two HIV-1 proteinase inhibitors, lopinavir and ritonavir, exhibited some signs of effectiveness against th...