Cytotoxicity of crude proanthocyanidin extract from purple glutinous rice bran (Oryza sativa L.) (Kum Doi Saket) compared with cyanidin 3-glucoside on X63 myeloma cancer cell lines

Proanthocyanidin and other phenolic compounds may potentially reduce the risk of cardiovascular diseases and cancer, as well as having antioxidant, anti-inflammatory and chemoprotective properties. Proanthocyanidin (PA) and cyanidin 3-glucoside (C3G), a polyphenolic compound of purple color found in...

Full description

Saved in:
Bibliographic Details
Main Authors: Montri Punyatong, Puntipa Pongpiachan, Petai Pongpiachan, Dumnern Karladee, Samlee Mankhetkorn
Format: Journal
Published: 2018
Subjects:
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=55949098788&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/60043
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Chiang Mai University
id th-cmuir.6653943832-60043
record_format dspace
spelling th-cmuir.6653943832-600432018-09-10T03:37:34Z Cytotoxicity of crude proanthocyanidin extract from purple glutinous rice bran (Oryza sativa L.) (Kum Doi Saket) compared with cyanidin 3-glucoside on X63 myeloma cancer cell lines Montri Punyatong Puntipa Pongpiachan Petai Pongpiachan Dumnern Karladee Samlee Mankhetkorn Agricultural and Biological Sciences Proanthocyanidin and other phenolic compounds may potentially reduce the risk of cardiovascular diseases and cancer, as well as having antioxidant, anti-inflammatory and chemoprotective properties. Proanthocyanidin (PA) and cyanidin 3-glucoside (C3G), a polyphenolic compound of purple color found in purple glutinous rice (Oryza sativa L.), may also manifest these positive effects. This research evaluated the effect of PA and C3G on X63, a mouse-plasma cancer cell line of myeloma cells. PA and C3G were extracted from the purple rice bran of a local, Thailand, purple, rice genotype (Kum Doi Saket). The results showed that the amount of C3G extract from the rice genotype was 54.47 mg/100 g rice bran. The cytotoxicity of the crude PA extract was demonstrated by a dose-dependent decrease in the percentage cell viability of the control in the PA group. A significant difference (p<0.05) began at 100 μg/ml and IC50 occurred at 62.29 μg/ml. The C3G extract also exhibited a dose-dependent decrease, but the significant difference (p<0.05) began at 10 μM and IC50 occurred at 8.4 μM. This research demonstrated a dose-related cytotoxic effect on cancer cells by the crude PA and C3G extracts from purple glutinous rice. The results indicated the benefit of the purple rice genotypes as a functional food with potential anticancer properties. 2018-09-10T03:37:34Z 2018-09-10T03:37:34Z 2008-10-01 Journal 00755192 2-s2.0-55949098788 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=55949098788&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/60043
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Agricultural and Biological Sciences
spellingShingle Agricultural and Biological Sciences
Montri Punyatong
Puntipa Pongpiachan
Petai Pongpiachan
Dumnern Karladee
Samlee Mankhetkorn
Cytotoxicity of crude proanthocyanidin extract from purple glutinous rice bran (Oryza sativa L.) (Kum Doi Saket) compared with cyanidin 3-glucoside on X63 myeloma cancer cell lines
description Proanthocyanidin and other phenolic compounds may potentially reduce the risk of cardiovascular diseases and cancer, as well as having antioxidant, anti-inflammatory and chemoprotective properties. Proanthocyanidin (PA) and cyanidin 3-glucoside (C3G), a polyphenolic compound of purple color found in purple glutinous rice (Oryza sativa L.), may also manifest these positive effects. This research evaluated the effect of PA and C3G on X63, a mouse-plasma cancer cell line of myeloma cells. PA and C3G were extracted from the purple rice bran of a local, Thailand, purple, rice genotype (Kum Doi Saket). The results showed that the amount of C3G extract from the rice genotype was 54.47 mg/100 g rice bran. The cytotoxicity of the crude PA extract was demonstrated by a dose-dependent decrease in the percentage cell viability of the control in the PA group. A significant difference (p<0.05) began at 100 μg/ml and IC50 occurred at 62.29 μg/ml. The C3G extract also exhibited a dose-dependent decrease, but the significant difference (p<0.05) began at 10 μM and IC50 occurred at 8.4 μM. This research demonstrated a dose-related cytotoxic effect on cancer cells by the crude PA and C3G extracts from purple glutinous rice. The results indicated the benefit of the purple rice genotypes as a functional food with potential anticancer properties.
format Journal
author Montri Punyatong
Puntipa Pongpiachan
Petai Pongpiachan
Dumnern Karladee
Samlee Mankhetkorn
author_facet Montri Punyatong
Puntipa Pongpiachan
Petai Pongpiachan
Dumnern Karladee
Samlee Mankhetkorn
author_sort Montri Punyatong
title Cytotoxicity of crude proanthocyanidin extract from purple glutinous rice bran (Oryza sativa L.) (Kum Doi Saket) compared with cyanidin 3-glucoside on X63 myeloma cancer cell lines
title_short Cytotoxicity of crude proanthocyanidin extract from purple glutinous rice bran (Oryza sativa L.) (Kum Doi Saket) compared with cyanidin 3-glucoside on X63 myeloma cancer cell lines
title_full Cytotoxicity of crude proanthocyanidin extract from purple glutinous rice bran (Oryza sativa L.) (Kum Doi Saket) compared with cyanidin 3-glucoside on X63 myeloma cancer cell lines
title_fullStr Cytotoxicity of crude proanthocyanidin extract from purple glutinous rice bran (Oryza sativa L.) (Kum Doi Saket) compared with cyanidin 3-glucoside on X63 myeloma cancer cell lines
title_full_unstemmed Cytotoxicity of crude proanthocyanidin extract from purple glutinous rice bran (Oryza sativa L.) (Kum Doi Saket) compared with cyanidin 3-glucoside on X63 myeloma cancer cell lines
title_sort cytotoxicity of crude proanthocyanidin extract from purple glutinous rice bran (oryza sativa l.) (kum doi saket) compared with cyanidin 3-glucoside on x63 myeloma cancer cell lines
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=55949098788&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/60043
_version_ 1681425363027099648