Superoxide-mediated proteasomal degradation of Bcl-2 determines cell susceptibility to Cr(VI)-induced apoptosis

• Main Authors: Neelam Azad, Anand Krishnan V. Iyer, Aranya Manosroi, Liying Wang, Yon Rojanasakul
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=49649083897&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/60153
• Institution: Chiang Mai University

Hexavalent chromium [Cr(VI)] compounds are redox cycling environmental carcinogens that induce apoptosis as the primary mode of cell death. Defects in apoptosis regulatory mechanisms contribute to carcinogenesis induced by Cr(VI). Activation of apoptosis signaling pathways is tightly linked with the...