Synthesis of castanospermine

• Main Authors: Theeraphan Machan, Andrew S. Davis, Boonsom Liawruangrath, Stephen G. Pyne
• 格式: 雜誌
• 出版: 2018
• 主題: Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• 在線閱讀: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=39149142197&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/60178

The diastereoselective synthesis of castanospermine is described in 11 synthetic steps from l-xylose. The borono-Mannich reaction between l-xylose, allylamine, and (E)-styrene boronic acid gives a tetrahydroxy amine with the desired configurations for C-6, C-7, C-8, and C-8a in the target molecule....