Underlying histopathology of HIV-infected women with squamous cell abnormalities on cervical cytology
This study was undertaken to evaluate the underlying histopathology of HIV-infected women who had abnormal cervical cytology. HIV-infected women with abnormal cervical cytology undergoing colposcopy at Chiang Mai University Hospital between January 2001 and February 2008 were reviewed. The cohorts w...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Journal |
| Published: |
2018
|
| Subjects: | |
| Online Access: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=67650917916&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/60187 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Chiang Mai University |
| Summary: | This study was undertaken to evaluate the underlying histopathology of HIV-infected women who had abnormal cervical cytology. HIV-infected women with abnormal cervical cytology undergoing colposcopy at Chiang Mai University Hospital between January 2001 and February 2008 were reviewed. The cohorts were matched and compared with an HIV-negative group. During the study period, 65 HIV-infected women with abnormal cervical cytology were available for review. The abnormal cervical smears were atypical squamous cell (9), low-grade squamous intraepithelial lesion (22), high-grade squamous intraepithelial lesion (27), and squamous cell carcinoma (7). When stratified by severity of abnormal cytology, HIV-infected women had a higher risk of having cervical intraepithelial neoplasia II or higher, whether the cervical smear showed low-grade (P=0.01) or high-grade abnormality (P=0.04) compared with the HIV negative group. After adjustment by age, parity, and menopausal status, HIV-infected women had 2.56 times the risk of having CIN II or higher (69.2% of HIV-infected women compared with 47.7% of HIV negative women; 95% CI=1.21-5.40, P=0.01). In conclusion, HIV-infected women with abnormal Pap smears are a population subset with higher risk of significant cervical lesions, irrespective of severity of abnormal cervical smears. |
|---|