Underlying histopathology of HIV-infected women with squamous cell abnormalities on cervical cytology

• Main Authors: Nongyao Suwankanta, Chumnan Kietpeerakool, Jatupol Srisomboon, Surapan Khunamornpong, Sumalee Siriaunkgul
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=67650917916&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/60187
• Institution: Chiang Mai University

This study was undertaken to evaluate the underlying histopathology of HIV-infected women who had abnormal cervical cytology. HIV-infected women with abnormal cervical cytology undergoing colposcopy at Chiang Mai University Hospital between January 2001 and February 2008 were reviewed. The cohorts were matched and compared with an HIV-negative group. During the study period, 65 HIV-infected women with abnormal cervical cytology were available for review. The abnormal cervical smears were atypical squamous cell (9), low-grade squamous intraepithelial lesion (22), high-grade squamous intraepithelial lesion (27), and squamous cell carcinoma (7). When stratified by severity of abnormal cytology, HIV-infected women had a higher risk of having cervical intraepithelial neoplasia II or higher, whether the cervical smear showed low-grade (P=0.01) or high-grade abnormality (P=0.04) compared with the HIV negative group. After adjustment by age, parity, and menopausal status, HIV-infected women had 2.56 times the risk of having CIN II or higher (69.2% of HIV-infected women compared with 47.7% of HIV negative women; 95% CI=1.21-5.40, P=0.01). In conclusion, HIV-infected women with abnormal Pap smears are a population subset with higher risk of significant cervical lesions, irrespective of severity of abnormal cervical smears.