Stemocurtisine, the first pyrido[1,2-a]azapine Stemona alkaloid

• Main Authors: Mungkornasawakul P., Pyne S.G., Jatisatienr A., Supyen D., Lie W., Ung A.T., Skelton B.W., White A.H.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-0041842662&partnerID=40&md5=e245b1fd9677be9375f8de44df55ff02; http://www.ncbi.nlm.nih.gov/pubmed/12880318; http://cmuir.cmu.ac.th/handle/6653943832/6031
• Institution: Chiang Mai University

A new pentacyclic stemona alkaloid, stemocurtisine (2), with a novel pyrido [1,2-a]azapine A,B-ring system, has been isolated from a root extract of Stemona curtisii. The structure and relative stereochemistry was determined by spectral data interpretation and X-ray crystallography.