A short amino acid sequence containing tyrosine in the N-terminal region of G protein-coupled receptors is critical for their potential use as coreceptors for human and simian immunodeficiency viruses

• Main Authors: Nobuaki Shimizu, Atsushi Tanaka, Atsushi Oue, Takahisa Mori, Chatchawann Apichartpiyakul, Hiroo Hoshino
• Format: Journal
• Published: 2018
• Subjects: Immunology and Microbiology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=58149388460&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/60458
• Institution: Chiang Mai University

Various G protein-coupled receptors (GPCRs) have the potential to work as co-receptors for human and simian immunodeficiency virus (HIV/SIV). HIV/SIV co-receptors have several tyrosines in their extracellular N-terminal region (NTR) as a common feature. However, the domain structure of the NTR that...