Multiple regions in dengue virus capsid protein contribute to nuclear localization during virus infection

• Main Authors: Sutha Sangiambut, Poonsook Keelapang, John Aaskov, Chunya Puttikhunt, Watchara Kasinrerk, Prida Malasit, Nopporn Sittisombut
• Format: Journal
• Published: 2018
• Subjects: Immunology and Microbiology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=44649173963&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/60479
• Institution: Chiang Mai University

During infection, the capsid (C) protein of many flaviviruses localizes to the nuclei and nucleoli of several infected cell lines; the underlying basis and significance of C protein nuclear localization remain poorly understood. In this study, double alanine-substitution mutations were introduced in...