A novel one-step biotransformation of cortexolone-21-acetate to hydrocortisone acetate using Cunninghamella blakesleeana ATCC 8688a

A novel one-step biotransformation of cortexolone-21-acetate to hydrocortisone acetate by nine microorganisms in various culturing conditions including the inoculum density, pH of the medium, amounts of the precursor and surfactant or oil containing medium was presented. The microorganisms used were...

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Main Authors: Jiradej Manosroi, Suda Saowakhon, Aranya Manosroi
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/60891
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-608912018-09-10T04:05:06Z A novel one-step biotransformation of cortexolone-21-acetate to hydrocortisone acetate using Cunninghamella blakesleeana ATCC 8688a Jiradej Manosroi Suda Saowakhon Aranya Manosroi Biochemistry, Genetics and Molecular Biology Immunology and Microbiology A novel one-step biotransformation of cortexolone-21-acetate to hydrocortisone acetate by nine microorganisms in various culturing conditions including the inoculum density, pH of the medium, amounts of the precursor and surfactant or oil containing medium was presented. The microorganisms used were Cunninghamella blakesleeana ATCC 8688a, C. blakesleeana ATCC 8688b, Curvularia lunata ATCC 12017, Aspergillus niger TISTR 3245, Curvularia sp. TISTR 3289, Curvularia sp. TISTR 3291, Cunninghamella echinulata F 1307943, C. lunata F 14894 and Penicillium sp. F 879414. C. blakesleeana ATCC 8688a gave the highest yield of 85.6 ± 6.2% at the initial cell number of 1 × 103CFU, pH 6.5 and incubated for 24 h. The result from this study can not only be applied for the chemical synthesis processes which involve the hydroxylation reaction, but also an attractive approach for industrial production because of lower cost, less time consuming and more environmental friendly. © 2007 Elsevier Inc. All rights reserved. 2018-09-10T04:00:55Z 2018-09-10T04:00:55Z 2007-08-02 Journal 01410229 2-s2.0-34248589992 10.1016/j.enzmictec.2007.02.014 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34248589992&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/60891
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Biochemistry, Genetics and Molecular Biology
Immunology and Microbiology
spellingShingle Biochemistry, Genetics and Molecular Biology
Immunology and Microbiology
Jiradej Manosroi
Suda Saowakhon
Aranya Manosroi
A novel one-step biotransformation of cortexolone-21-acetate to hydrocortisone acetate using Cunninghamella blakesleeana ATCC 8688a
description A novel one-step biotransformation of cortexolone-21-acetate to hydrocortisone acetate by nine microorganisms in various culturing conditions including the inoculum density, pH of the medium, amounts of the precursor and surfactant or oil containing medium was presented. The microorganisms used were Cunninghamella blakesleeana ATCC 8688a, C. blakesleeana ATCC 8688b, Curvularia lunata ATCC 12017, Aspergillus niger TISTR 3245, Curvularia sp. TISTR 3289, Curvularia sp. TISTR 3291, Cunninghamella echinulata F 1307943, C. lunata F 14894 and Penicillium sp. F 879414. C. blakesleeana ATCC 8688a gave the highest yield of 85.6 ± 6.2% at the initial cell number of 1 × 103CFU, pH 6.5 and incubated for 24 h. The result from this study can not only be applied for the chemical synthesis processes which involve the hydroxylation reaction, but also an attractive approach for industrial production because of lower cost, less time consuming and more environmental friendly. © 2007 Elsevier Inc. All rights reserved.
format Journal
author Jiradej Manosroi
Suda Saowakhon
Aranya Manosroi
author_facet Jiradej Manosroi
Suda Saowakhon
Aranya Manosroi
author_sort Jiradej Manosroi
title A novel one-step biotransformation of cortexolone-21-acetate to hydrocortisone acetate using Cunninghamella blakesleeana ATCC 8688a
title_short A novel one-step biotransformation of cortexolone-21-acetate to hydrocortisone acetate using Cunninghamella blakesleeana ATCC 8688a
title_full A novel one-step biotransformation of cortexolone-21-acetate to hydrocortisone acetate using Cunninghamella blakesleeana ATCC 8688a
title_fullStr A novel one-step biotransformation of cortexolone-21-acetate to hydrocortisone acetate using Cunninghamella blakesleeana ATCC 8688a
title_full_unstemmed A novel one-step biotransformation of cortexolone-21-acetate to hydrocortisone acetate using Cunninghamella blakesleeana ATCC 8688a
title_sort novel one-step biotransformation of cortexolone-21-acetate to hydrocortisone acetate using cunninghamella blakesleeana atcc 8688a
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34248589992&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/60891
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