Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin

• Main Authors: Pornngarm Limtrakul, Wanida Chearwae, Suneet Shukla, Chada Phisalphong, Suresh V. Ambudkar
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34447506459&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/60919
• Institution: Chiang Mai University

Many studies have been performed with the aim of developing effective resistance modulators to overcome the multidrug resistance (MDR) of human cancers. Potent MDR modulators are being investigated in clinical trials. Many current studies are focused on dietary herbs due to the fact that these have...