Effect of Alpinia galanga extract on cartilage degradation and on gene expression in human chondrocyte and synovial fibroblast metabolism

• Main Authors: Peraphan Pothacharoen, Kanyamas Choocheep, Tanyaluck Pitak, Wilart Pompimon, Bhusana Premanode, Timothy E. Hardingham, Prachya Kongtawelert
• Format: Journal
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Neuroscience
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33748299365&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/61445
• Institution: Chiang Mai University

We investigated the effects of A. galanga extract on metabolism and gene expression involved in the interleukin-1β (IL-1β) response of human chondrocyte and synovial fibroblast. A. galanga extract inhibited IL-1β enhanced matrix breakdown of the cartilage explants in a dose-dependent manner. It supp...