Iron-chelating and free-radical scavenging activities of microwave-processed green tea in iron overload
Secondary iron overload is found in β-thalassemia (thal) patients because of increased dietary iron absorption and multiple blood transfusions. Excessive iron catalyzes free-radical generation, leading to oxidative damage and vital organ dysfunction. Non-transferrin-bound iron (NTBI) detected in tha...
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th-cmuir.6653943832-615162018-09-11T09:00:15Z Iron-chelating and free-radical scavenging activities of microwave-processed green tea in iron overload Somdet Srichairatanakool Sakaewan Ounjaijean Chonthida Thephinlap Udompun Khansuwan Chada Phisalpong Suthat Fucharoen Biochemistry, Genetics and Molecular Biology Medicine Secondary iron overload is found in β-thalassemia (thal) patients because of increased dietary iron absorption and multiple blood transfusions. Excessive iron catalyzes free-radical generation, leading to oxidative damage and vital organ dysfunction. Non-transferrin-bound iron (NTBI) detected in thalassemic plasma is highly toxic and chelatable. Though used to treat iron overload, desferrioxamine (DFO) and deferiprone (L1) also have adverse effects. Green tea (GT) shows many pharmacological effects, particularly antioxidative and iron-chelating capacities. This study was performed to investigate the ability of GT extracts to reduce plasma NTBI concentration and oxidative stress in vitro. The Fe3+was found to bind to GT crude extract and form a complex. Green tea crude extract time- and dose-dependently decreased plasma NTBI concentration and counteracted the increase of oxidative stress in both Fe2+-EDTA-treated human plasma and erythrocytes. Green tea is a bifunctional natural product that could be relevant for management of iron overload and oxidative stress. Copyright © Taylor & Francis Group, LLC. 2018-09-11T08:54:29Z 2018-09-11T08:54:29Z 2006-07-01 Journal 1532432X 03630269 2-s2.0-33745519058 10.1080/03630260600642666 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33745519058&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/61516 |
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Biochemistry, Genetics and Molecular Biology Medicine Somdet Srichairatanakool Sakaewan Ounjaijean Chonthida Thephinlap Udompun Khansuwan Chada Phisalpong Suthat Fucharoen Iron-chelating and free-radical scavenging activities of microwave-processed green tea in iron overload |
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Secondary iron overload is found in β-thalassemia (thal) patients because of increased dietary iron absorption and multiple blood transfusions. Excessive iron catalyzes free-radical generation, leading to oxidative damage and vital organ dysfunction. Non-transferrin-bound iron (NTBI) detected in thalassemic plasma is highly toxic and chelatable. Though used to treat iron overload, desferrioxamine (DFO) and deferiprone (L1) also have adverse effects. Green tea (GT) shows many pharmacological effects, particularly antioxidative and iron-chelating capacities. This study was performed to investigate the ability of GT extracts to reduce plasma NTBI concentration and oxidative stress in vitro. The Fe3+was found to bind to GT crude extract and form a complex. Green tea crude extract time- and dose-dependently decreased plasma NTBI concentration and counteracted the increase of oxidative stress in both Fe2+-EDTA-treated human plasma and erythrocytes. Green tea is a bifunctional natural product that could be relevant for management of iron overload and oxidative stress. Copyright © Taylor & Francis Group, LLC. |
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Somdet Srichairatanakool Sakaewan Ounjaijean Chonthida Thephinlap Udompun Khansuwan Chada Phisalpong Suthat Fucharoen |
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Somdet Srichairatanakool Sakaewan Ounjaijean Chonthida Thephinlap Udompun Khansuwan Chada Phisalpong Suthat Fucharoen |
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Somdet Srichairatanakool |
title |
Iron-chelating and free-radical scavenging activities of microwave-processed green tea in iron overload |
title_short |
Iron-chelating and free-radical scavenging activities of microwave-processed green tea in iron overload |
title_full |
Iron-chelating and free-radical scavenging activities of microwave-processed green tea in iron overload |
title_fullStr |
Iron-chelating and free-radical scavenging activities of microwave-processed green tea in iron overload |
title_full_unstemmed |
Iron-chelating and free-radical scavenging activities of microwave-processed green tea in iron overload |
title_sort |
iron-chelating and free-radical scavenging activities of microwave-processed green tea in iron overload |
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2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33745519058&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/61516 |
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