Geographical distribution and disease associations of the CD45 exon 6 138G variant

• Main Authors: Victoria Ward, Branwen J. Hennig, Kouzo Hirai, Hideki Tahara, Akihiro Tamori, Ritu Dawes, Mineki Saito, Charles Bangham, Henry Stephens, Anne E. Goldfeld, Warunee Kunachiwa, Nipapan Leetrakool, Julian Hopkin, Sarah Dunstan, Adrian Hill, Walter Bodmer, Peter C.L. Beverley, Elma Z. Tchilian
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33645460228&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/61534
• Institution: Chiang Mai University

CD45 is crucial for normal lymphocyte signalling, and altered CD45 expression has major effects on immune function. Both mice and humans lacking CD45 expression are severely immunodeficient, and single-nucleotide polymorphisms in the CD45 gene that cause altered splicing have been associated with au...