Wnt pathway component LEF1 mediates tumor cell invasion and is expressed in human and murine breast cancers lacking ErbB2 (her-2/neu) overexpression

• Main Authors: Anthony Nguyen, Andrea Rosner, Tatjana Milovanovic, Christopher Hope, Kestutis Planutis, Baisakhi Saha, Benjaporn Chaiwun, Fritz Lin, S. Ashraf Imam, J. Lawrence Marsh, Randall F. Holcombe
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33644828252&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/62085
• Institution: Chiang Mai University

This study examines the role of LEF1, a component of the Wnt signaling pathway, in human breast and murine mammary carcinoma and its relationship to ErbB2 (her-2/neu) expression. Mammary tissue and tumors from 5 different Wnt pathway-activated transgenic mouse strains and 5 different ErbB2 pathway-a...