Selective small molecule peptidomimetic ligands of TrkC and TrkA receptors afford discrete or complete neurotrophic activities

• Main Authors: Maria Clara Zaccaro, Boon Lee Hong, Mookda Pattarawarapan, Zebin Xia, Antoine Caron, Pierrre Jean L'Heureux, Yoshua Bengio, Kevin Burgess, H. Uri Saragovi
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=25144497042&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/62092
• Institution: Chiang Mai University

We designed a minilibrary of 55 small molecule peptidomimetics based on β-turns of the neurotrophin growth factor polypeptides neurotrophin-3 (NT-3) and nerve growth factor (NGF). Direct binding, binding competition, and biological screens identified agonistic ligands of the ectodomain of the neurot...