Selective small molecule peptidomimetic ligands of TrkC and TrkA receptors afford discrete or complete neurotrophic activities

We designed a minilibrary of 55 small molecule peptidomimetics based on β-turns of the neurotrophin growth factor polypeptides neurotrophin-3 (NT-3) and nerve growth factor (NGF). Direct binding, binding competition, and biological screens identified agonistic ligands of the ectodomain of the neurot...

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Bibliographic Details
Main Authors: Maria Clara Zaccaro, Boon Lee Hong, Mookda Pattarawarapan, Zebin Xia, Antoine Caron, Pierrre Jean L'Heureux, Yoshua Bengio, Kevin Burgess, H. Uri Saragovi
Format: Journal
Published: 2018
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Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=25144497042&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/62092
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Institution: Chiang Mai University
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