Antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of Scleropyrum wallichianum
From the twigs of Scleropyrum wallichianum, a new unsaturated carboxylic acid, scleropyric acid (1), two new esters, β-sitosteryl-3-O-scleropyrate (2) and stigmasteryl-3-O-scleropyrate (3), and two well-known sterols, β-sitosterol (4) and stigmasterol (5), were isolated and characterized using spect...
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| Main Authors: | , , , , , |
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| Format: | Journal |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=26444447960&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/62144 |
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| Institution: | Chiang Mai University |
| Summary: | From the twigs of Scleropyrum wallichianum, a new unsaturated carboxylic acid, scleropyric acid (1), two new esters, β-sitosteryl-3-O-scleropyrate (2) and stigmasteryl-3-O-scleropyrate (3), and two well-known sterols, β-sitosterol (4) and stigmasterol (5), were isolated and characterized using spectroscopic methods. Compound 1 exhibited antimycobacterial activity with an MIC value of 25 μg/ml and showed antiplasmodial activity with an IC50 value of 7.2 μg/ml. Compounds 2 and 3 were inactive in both assays. © 2005 Pharmaceutical Society of Japan. |
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