Antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of Scleropyrum wallichianum

From the twigs of Scleropyrum wallichianum, a new unsaturated carboxylic acid, scleropyric acid (1), two new esters, β-sitosteryl-3-O-scleropyrate (2) and stigmasteryl-3-O-scleropyrate (3), and two well-known sterols, β-sitosterol (4) and stigmasterol (5), were isolated and characterized using spect...

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Main Authors:	Apichart Suksamrarn, Matee Buaprom, Saifon Udtip, Nuchnipa Nuntawong, Rachada Haritakun, Somdej Kanokmedhakul
Format:	Journal
Published:	2018
Subjects:	Chemistry Pharmacology, Toxicology and Pharmaceutics
Online Access:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=26444447960&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/62144
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Institution:	Chiang Mai University

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spelling	th-cmuir.6653943832-621442018-09-11T09:27:46Z Antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of Scleropyrum wallichianum Apichart Suksamrarn Matee Buaprom Saifon Udtip Nuchnipa Nuntawong Rachada Haritakun Somdej Kanokmedhakul Chemistry Pharmacology, Toxicology and Pharmaceutics From the twigs of Scleropyrum wallichianum, a new unsaturated carboxylic acid, scleropyric acid (1), two new esters, β-sitosteryl-3-O-scleropyrate (2) and stigmasteryl-3-O-scleropyrate (3), and two well-known sterols, β-sitosterol (4) and stigmasterol (5), were isolated and characterized using spectroscopic methods. Compound 1 exhibited antimycobacterial activity with an MIC value of 25 μg/ml and showed antiplasmodial activity with an IC50 value of 7.2 μg/ml. Compounds 2 and 3 were inactive in both assays. © 2005 Pharmaceutical Society of Japan. 2018-09-11T09:22:32Z 2018-09-11T09:22:32Z 2005-10-01 Journal 13475223 00092363 2-s2.0-26444447960 10.1248/cpb.53.1327 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=26444447960&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/62144
institution	Chiang Mai University
building	Chiang Mai University Library
country	Thailand
collection	CMU Intellectual Repository
topic	Chemistry Pharmacology, Toxicology and Pharmaceutics
spellingShingle	Chemistry Pharmacology, Toxicology and Pharmaceutics Apichart Suksamrarn Matee Buaprom Saifon Udtip Nuchnipa Nuntawong Rachada Haritakun Somdej Kanokmedhakul Antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of Scleropyrum wallichianum
description	From the twigs of Scleropyrum wallichianum, a new unsaturated carboxylic acid, scleropyric acid (1), two new esters, β-sitosteryl-3-O-scleropyrate (2) and stigmasteryl-3-O-scleropyrate (3), and two well-known sterols, β-sitosterol (4) and stigmasterol (5), were isolated and characterized using spectroscopic methods. Compound 1 exhibited antimycobacterial activity with an MIC value of 25 μg/ml and showed antiplasmodial activity with an IC50 value of 7.2 μg/ml. Compounds 2 and 3 were inactive in both assays. © 2005 Pharmaceutical Society of Japan.
format	Journal
author	Apichart Suksamrarn Matee Buaprom Saifon Udtip Nuchnipa Nuntawong Rachada Haritakun Somdej Kanokmedhakul
author_facet	Apichart Suksamrarn Matee Buaprom Saifon Udtip Nuchnipa Nuntawong Rachada Haritakun Somdej Kanokmedhakul
author_sort	Apichart Suksamrarn
title	Antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of Scleropyrum wallichianum
title_short	Antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of Scleropyrum wallichianum
title_full	Antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of Scleropyrum wallichianum
title_fullStr	Antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of Scleropyrum wallichianum
title_full_unstemmed	Antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of Scleropyrum wallichianum
title_sort	antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of scleropyrum wallichianum
publishDate	2018
url	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=26444447960&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/62144
_version_	1681425752226004992

Antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of Scleropyrum wallichianum

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