Thermodynamic investigations on the inclusion complexation of piroxicam with cyclodextrin derivatives

Thermodynamic studies of piroxicam in aqueous solution complexed with β-cyclodextrin (β-CD), γ-cyclodextrin (γ-CD) and two β-cyclodextrin derivatives, hydroxypropyl-β-cyclodextrin (HP-β-CD) and methyl-β-cyclodextrin (Me-β-CD) were performed at different temperatures and pH values using the phase sol...

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Main Authors: S. Charumanee, P. Weiss-Greiler, P. Wolschann, H. Viernstein, A. Titwan, J. Sirithunyalug, S. Okonogi
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/62460
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spelling th-cmuir.6653943832-624602018-09-11T09:27:46Z Thermodynamic investigations on the inclusion complexation of piroxicam with cyclodextrin derivatives S. Charumanee P. Weiss-Greiler P. Wolschann H. Viernstein A. Titwan J. Sirithunyalug S. Okonogi Pharmacology, Toxicology and Pharmaceutics Thermodynamic studies of piroxicam in aqueous solution complexed with β-cyclodextrin (β-CD), γ-cyclodextrin (γ-CD) and two β-cyclodextrin derivatives, hydroxypropyl-β-cyclodextrin (HP-β-CD) and methyl-β-cyclodextrin (Me-β-CD) were performed at different temperatures and pH values using the phase solubility method. The phase solubility diagrams of β-CD, γ-CD and HP-β-CD is of A L-type behavior, indicating the formation of 1:1 complexes. The related stability constants range from β-CD > γ-CD > Me-γ-CD > HP-β-CD, respectively. An A P-type solubility diagram is observed for Me-β-CD, indicating the formation of 1:2 complexes at higher CD concentrations. From the temperature dependence of the equilibrium constants the reaction enthalpies and entropies have been determined. The contributions of the reaction entropies are small and no enthalpy-entropy- compensation is observed, except for γ-CD, where a very small negative reaction entropy could be estimated. Moreover, the influence of the pH value is rather high, because the differently charged forms of piroxicam show different solubility behavior in water. © Österreichische Apotheker- Verlagsgesellschaft m. b. H. 2018-09-11T09:27:46Z 2018-09-11T09:27:46Z 2005-09-30 Journal 22180532 00368709 2-s2.0-27144471930 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=27144471930&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/62460
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Pharmacology, Toxicology and Pharmaceutics
spellingShingle Pharmacology, Toxicology and Pharmaceutics
S. Charumanee
P. Weiss-Greiler
P. Wolschann
H. Viernstein
A. Titwan
J. Sirithunyalug
S. Okonogi
Thermodynamic investigations on the inclusion complexation of piroxicam with cyclodextrin derivatives
description Thermodynamic studies of piroxicam in aqueous solution complexed with β-cyclodextrin (β-CD), γ-cyclodextrin (γ-CD) and two β-cyclodextrin derivatives, hydroxypropyl-β-cyclodextrin (HP-β-CD) and methyl-β-cyclodextrin (Me-β-CD) were performed at different temperatures and pH values using the phase solubility method. The phase solubility diagrams of β-CD, γ-CD and HP-β-CD is of A L-type behavior, indicating the formation of 1:1 complexes. The related stability constants range from β-CD > γ-CD > Me-γ-CD > HP-β-CD, respectively. An A P-type solubility diagram is observed for Me-β-CD, indicating the formation of 1:2 complexes at higher CD concentrations. From the temperature dependence of the equilibrium constants the reaction enthalpies and entropies have been determined. The contributions of the reaction entropies are small and no enthalpy-entropy- compensation is observed, except for γ-CD, where a very small negative reaction entropy could be estimated. Moreover, the influence of the pH value is rather high, because the differently charged forms of piroxicam show different solubility behavior in water. © Österreichische Apotheker- Verlagsgesellschaft m. b. H.
format Journal
author S. Charumanee
P. Weiss-Greiler
P. Wolschann
H. Viernstein
A. Titwan
J. Sirithunyalug
S. Okonogi
author_facet S. Charumanee
P. Weiss-Greiler
P. Wolschann
H. Viernstein
A. Titwan
J. Sirithunyalug
S. Okonogi
author_sort S. Charumanee
title Thermodynamic investigations on the inclusion complexation of piroxicam with cyclodextrin derivatives
title_short Thermodynamic investigations on the inclusion complexation of piroxicam with cyclodextrin derivatives
title_full Thermodynamic investigations on the inclusion complexation of piroxicam with cyclodextrin derivatives
title_fullStr Thermodynamic investigations on the inclusion complexation of piroxicam with cyclodextrin derivatives
title_full_unstemmed Thermodynamic investigations on the inclusion complexation of piroxicam with cyclodextrin derivatives
title_sort thermodynamic investigations on the inclusion complexation of piroxicam with cyclodextrin derivatives
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=27144471930&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/62460
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