Potential anti-mutagenicity, antioxidant, and anti-inflammatory capacities of the extract from perilla seed meal

© 2018 Wiley Periodicals, Inc. The objective of this study was to investigate the in vitro bioactivities associated with the content of phytochemicals in the extracts from perilla seed meal extract (PSME) compared with dietary seed (PSE). PSE had higher total phenolics and flavonoids content than PS...

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Main Authors: Orada Chumphukam, Komsak Pintha, Chakkrit Khanaree, Teera Chewonarin, Wittaya Chaiwangyen, Payungsak Tantipaiboonwong, Maitree Suttajit, Orawan Khantamat
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Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/62509
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-625092018-11-29T07:55:52Z Potential anti-mutagenicity, antioxidant, and anti-inflammatory capacities of the extract from perilla seed meal Orada Chumphukam Komsak Pintha Chakkrit Khanaree Teera Chewonarin Wittaya Chaiwangyen Payungsak Tantipaiboonwong Maitree Suttajit Orawan Khantamat Agricultural and Biological Sciences Biochemistry, Genetics and Molecular Biology Pharmacology, Toxicology and Pharmaceutics © 2018 Wiley Periodicals, Inc. The objective of this study was to investigate the in vitro bioactivities associated with the content of phytochemicals in the extracts from perilla seed meal extract (PSME) compared with dietary seed (PSE). PSE had higher total phenolics and flavonoids content than PSME. However, hydrophilic phytochemical contents in PSME were quantitatively equivalent to PSE. Rosmarinic acid was predominantly found in both extracts. Cell viability and anti-mutagenicity testing demonstrated that PSE and PSME were biosecured and non-genotoxic. Both extracts strongly scavenged free radicals and significantly reduced reactive oxygen species (ROS) production. The extracts drastically diminished nitric oxide (NO) production of LPS-treated RAW 264.7 cells via iNOS mRNA expression. The expression of IL-6 and COX-2 were evidently inhibited by these extracts. It could be concluded that PSE and PSME clearly showed in vitro anti-mutagenicity, antioxidant and anti-inflammatory capacities. In particular, the by-product perilla seed meal could be considered as a high nutritive functional food. Practical applications: This study suggests that the seed meals, a by-product from seed oil industry, can be utilized as a valuable dietary source for humans and animals. The high content of polyphenols and their bioactivities can be developed as functional foods, and excipients and fillers in pharmaceuticals and nutraceuticals production. Moreover, recycling of the by-product seed meals should also reduce environmental and sanitary pollution. 2018-11-29T07:29:40Z 2018-11-29T07:29:40Z 2018-10-01 Journal 17454514 01458884 2-s2.0-85046435035 10.1111/jfbc.12556 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85046435035&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/62509
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Agricultural and Biological Sciences
Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics
spellingShingle Agricultural and Biological Sciences
Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics
Orada Chumphukam
Komsak Pintha
Chakkrit Khanaree
Teera Chewonarin
Wittaya Chaiwangyen
Payungsak Tantipaiboonwong
Maitree Suttajit
Orawan Khantamat
Potential anti-mutagenicity, antioxidant, and anti-inflammatory capacities of the extract from perilla seed meal
description © 2018 Wiley Periodicals, Inc. The objective of this study was to investigate the in vitro bioactivities associated with the content of phytochemicals in the extracts from perilla seed meal extract (PSME) compared with dietary seed (PSE). PSE had higher total phenolics and flavonoids content than PSME. However, hydrophilic phytochemical contents in PSME were quantitatively equivalent to PSE. Rosmarinic acid was predominantly found in both extracts. Cell viability and anti-mutagenicity testing demonstrated that PSE and PSME were biosecured and non-genotoxic. Both extracts strongly scavenged free radicals and significantly reduced reactive oxygen species (ROS) production. The extracts drastically diminished nitric oxide (NO) production of LPS-treated RAW 264.7 cells via iNOS mRNA expression. The expression of IL-6 and COX-2 were evidently inhibited by these extracts. It could be concluded that PSE and PSME clearly showed in vitro anti-mutagenicity, antioxidant and anti-inflammatory capacities. In particular, the by-product perilla seed meal could be considered as a high nutritive functional food. Practical applications: This study suggests that the seed meals, a by-product from seed oil industry, can be utilized as a valuable dietary source for humans and animals. The high content of polyphenols and their bioactivities can be developed as functional foods, and excipients and fillers in pharmaceuticals and nutraceuticals production. Moreover, recycling of the by-product seed meals should also reduce environmental and sanitary pollution.
format Journal
author Orada Chumphukam
Komsak Pintha
Chakkrit Khanaree
Teera Chewonarin
Wittaya Chaiwangyen
Payungsak Tantipaiboonwong
Maitree Suttajit
Orawan Khantamat
author_facet Orada Chumphukam
Komsak Pintha
Chakkrit Khanaree
Teera Chewonarin
Wittaya Chaiwangyen
Payungsak Tantipaiboonwong
Maitree Suttajit
Orawan Khantamat
author_sort Orada Chumphukam
title Potential anti-mutagenicity, antioxidant, and anti-inflammatory capacities of the extract from perilla seed meal
title_short Potential anti-mutagenicity, antioxidant, and anti-inflammatory capacities of the extract from perilla seed meal
title_full Potential anti-mutagenicity, antioxidant, and anti-inflammatory capacities of the extract from perilla seed meal
title_fullStr Potential anti-mutagenicity, antioxidant, and anti-inflammatory capacities of the extract from perilla seed meal
title_full_unstemmed Potential anti-mutagenicity, antioxidant, and anti-inflammatory capacities of the extract from perilla seed meal
title_sort potential anti-mutagenicity, antioxidant, and anti-inflammatory capacities of the extract from perilla seed meal
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85046435035&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/62509
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