Mechanochemical synthesis of primary amides from carboxylic acids using TCT/NH<inf>4</inf>SCN

• Main Authors: Subin Jaita, Wong Phakhodee, Neeranuch Chairungsi, Mookda Pattarawarapan
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85052623821&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/62562
• Institution: Chiang Mai University

© 2018 A facile and effective approach toward the synthesis of primary amides from carboxylic acids has been developed. In the presence of 2,4,6-trichloro-1,3,5-triazine, a combination of ammonium thiocyanate and potassium carbonate led to the rapid conversion of carboxylic acids into the corresponding amides within five minutes grinding at room temperature. The use of ammonium thiocyanate as the amine source is unprecedented and exclusive formation of primary amides is observed only under the liquid-assisted grinding conditions.