Molecular modeling investigation of the potential mechanism for phytochemical-induced skin collagen biosynthesis by inhibition of the protein phosphatase 1 holoenzyme

• Main Authors: Pathomwat Wongrattanakamon, Piyarat Nimmanpipug, Busaban Sirithunyalug, Chalermpong Saenjum, Supat Jiranusornkul
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85054492570&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/62587
• Institution: Chiang Mai University

© 2018, Springer Science+Business Media, LLC, part of Springer Nature. The most prominent feature of UV-induced photoaged skin is decreased type 1 procollagen. Increase of the TGF-β/Smad signaling through inhibition of the TβRI dephosphorylation by the GADD34–PP1c phosphatase complex represents a pr...