A convenient one-pot synthesis of: N -substituted amidoximes and their application toward 1,2,4-oxadiazol-5-ones

A convenient one-pot synthesis of: N -substituted amidoximes and their application toward 1,2,4-oxadiazol-5-ones

© 2018 The Royal Society of Chemistry. The first direct one-pot approach for the synthesis of N-substituted amidoximes from secondary amides or the intermediate amides has been developed. Through the Ph3P-I2-mediated dehydrative condensation, a variety of N-aryl and N-alkyl amidoximes (R1(CNOH)NHR2,...

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Main Authors: Wong Phakhodee, Chuthamat Duangkamol, Nitaya Wiriya, Mookda Pattarawarapan
Format: Journal
Published: 2018
Subjects:
Chemical Engineering
Chemistry
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85057227709&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/62963
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Institution: Chiang Mai University
id th-cmuir.6653943832-62963
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spelling th-cmuir.6653943832-629632018-12-14T03:51:26Z A convenient one-pot synthesis of: N -substituted amidoximes and their application toward 1,2,4-oxadiazol-5-ones Wong Phakhodee Chuthamat Duangkamol Nitaya Wiriya Mookda Pattarawarapan Chemical Engineering Chemistry © 2018 The Royal Society of Chemistry. The first direct one-pot approach for the synthesis of N-substituted amidoximes from secondary amides or the intermediate amides has been developed. Through the Ph3P-I2-mediated dehydrative condensation, a variety of N-aryl and N-alkyl amidoximes (R1(CNOH)NHR2, where R1 or R2 = aryl, alkyl, or benzyl) were readily afforded under mild conditions and short reaction times. The synthetic application of the obtained amidoximes has also been demonstrated through the formation of 1,2,4-oxadiazolones via base-mediated carbonylative cyclization with 1,1′-carbonyldiimidazole. 2018-12-14T03:49:47Z 2018-12-14T03:49:47Z 2018-01-01 Journal 20462069 2-s2.0-85057227709 10.1039/c8ra08207c https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85057227709&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/62963
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Chemical Engineering
Chemistry
spellingShingle Chemical Engineering
Chemistry
Wong Phakhodee
Chuthamat Duangkamol
Nitaya Wiriya
Mookda Pattarawarapan
A convenient one-pot synthesis of: N -substituted amidoximes and their application toward 1,2,4-oxadiazol-5-ones
description © 2018 The Royal Society of Chemistry. The first direct one-pot approach for the synthesis of N-substituted amidoximes from secondary amides or the intermediate amides has been developed. Through the Ph3P-I2-mediated dehydrative condensation, a variety of N-aryl and N-alkyl amidoximes (R1(CNOH)NHR2, where R1 or R2 = aryl, alkyl, or benzyl) were readily afforded under mild conditions and short reaction times. The synthetic application of the obtained amidoximes has also been demonstrated through the formation of 1,2,4-oxadiazolones via base-mediated carbonylative cyclization with 1,1′-carbonyldiimidazole.
format Journal
author Wong Phakhodee
Chuthamat Duangkamol
Nitaya Wiriya
Mookda Pattarawarapan
author_facet Wong Phakhodee
Chuthamat Duangkamol
Nitaya Wiriya
Mookda Pattarawarapan
author_sort Wong Phakhodee
title A convenient one-pot synthesis of: N -substituted amidoximes and their application toward 1,2,4-oxadiazol-5-ones
title_short A convenient one-pot synthesis of: N -substituted amidoximes and their application toward 1,2,4-oxadiazol-5-ones
title_full A convenient one-pot synthesis of: N -substituted amidoximes and their application toward 1,2,4-oxadiazol-5-ones
title_fullStr A convenient one-pot synthesis of: N -substituted amidoximes and their application toward 1,2,4-oxadiazol-5-ones
title_full_unstemmed A convenient one-pot synthesis of: N -substituted amidoximes and their application toward 1,2,4-oxadiazol-5-ones
title_sort convenient one-pot synthesis of: n -substituted amidoximes and their application toward 1,2,4-oxadiazol-5-ones
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85057227709&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/62963
_version_ 1681425903982215168

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