Kinetic Study of Ibuprofen Release from a pH- and Temperature-sensitive Hydrogel, Based on Poly(styrene-alt-maleic anhydride) Copolymer

The development of amphiphilic copolymers with pH- and temperature-responsive properties by grafting isopropyl amine and poly(ethylene glycol) monomethyl ether onto poly(styrene-alt-maleic anhydride) copolymer for drug delivery of ibuprofen as the model drug is reported. The modified hydrogel matri...

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Main Authors: Morteza Bahram, Fariba Hoseinpour, Naimeh Mohseni, Peyman Najafi-Moghaddam
Format: บทความวารสาร
Language:English
Published: Science Faculty of Chiang Mai University 2019
Online Access:http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=7675
http://cmuir.cmu.ac.th/jspui/handle/6653943832/63849
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spelling th-cmuir.6653943832-638492019-05-07T09:57:22Z Kinetic Study of Ibuprofen Release from a pH- and Temperature-sensitive Hydrogel, Based on Poly(styrene-alt-maleic anhydride) Copolymer Morteza Bahram Fariba Hoseinpour Naimeh Mohseni Peyman Najafi-Moghaddam The development of amphiphilic copolymers with pH- and temperature-responsive properties by grafting isopropyl amine and poly(ethylene glycol) monomethyl ether onto poly(styrene-alt-maleic anhydride) copolymer for drug delivery of ibuprofen as the model drug is reported. The modified hydrogel matrices were studied by FT-IR spectroscopy. The synthesized hydrogel behaves as a “smart” dual-responsive material showing transition at the temperature/pH values close to the physiological ones. Hence, swelling and release kinetic studies were performed at 37 °C in acid medium, at pH=3, for mimicking conditions of the gastric fluid in the stomach. The release of the drug was monitored by UV-Vis. spectrophotometer. In order to study the release kinetics, experimental data obtained from in vitro drug release were approximated by several mathematical models including zero-order, first-order, Hixson-Crowell and Korsmeyer-Peppas to determine the kinetics of drug release from drug delivery systems. The quantitative analysis can ultimately help to yield information on the efficacy of various release models. The results obtained showed that the Korsemeyer–Pappas model fits well to data of ibuprofen release. 2019-05-07T09:57:22Z 2019-05-07T09:57:22Z 2017 บทความวารสาร 0125-2526 http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=7675 http://cmuir.cmu.ac.th/jspui/handle/6653943832/63849 Eng Science Faculty of Chiang Mai University
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description The development of amphiphilic copolymers with pH- and temperature-responsive properties by grafting isopropyl amine and poly(ethylene glycol) monomethyl ether onto poly(styrene-alt-maleic anhydride) copolymer for drug delivery of ibuprofen as the model drug is reported. The modified hydrogel matrices were studied by FT-IR spectroscopy. The synthesized hydrogel behaves as a “smart” dual-responsive material showing transition at the temperature/pH values close to the physiological ones. Hence, swelling and release kinetic studies were performed at 37 °C in acid medium, at pH=3, for mimicking conditions of the gastric fluid in the stomach. The release of the drug was monitored by UV-Vis. spectrophotometer. In order to study the release kinetics, experimental data obtained from in vitro drug release were approximated by several mathematical models including zero-order, first-order, Hixson-Crowell and Korsmeyer-Peppas to determine the kinetics of drug release from drug delivery systems. The quantitative analysis can ultimately help to yield information on the efficacy of various release models. The results obtained showed that the Korsemeyer–Pappas model fits well to data of ibuprofen release.
format บทความวารสาร
author Morteza Bahram
Fariba Hoseinpour
Naimeh Mohseni
Peyman Najafi-Moghaddam
spellingShingle Morteza Bahram
Fariba Hoseinpour
Naimeh Mohseni
Peyman Najafi-Moghaddam
Kinetic Study of Ibuprofen Release from a pH- and Temperature-sensitive Hydrogel, Based on Poly(styrene-alt-maleic anhydride) Copolymer
author_facet Morteza Bahram
Fariba Hoseinpour
Naimeh Mohseni
Peyman Najafi-Moghaddam
author_sort Morteza Bahram
title Kinetic Study of Ibuprofen Release from a pH- and Temperature-sensitive Hydrogel, Based on Poly(styrene-alt-maleic anhydride) Copolymer
title_short Kinetic Study of Ibuprofen Release from a pH- and Temperature-sensitive Hydrogel, Based on Poly(styrene-alt-maleic anhydride) Copolymer
title_full Kinetic Study of Ibuprofen Release from a pH- and Temperature-sensitive Hydrogel, Based on Poly(styrene-alt-maleic anhydride) Copolymer
title_fullStr Kinetic Study of Ibuprofen Release from a pH- and Temperature-sensitive Hydrogel, Based on Poly(styrene-alt-maleic anhydride) Copolymer
title_full_unstemmed Kinetic Study of Ibuprofen Release from a pH- and Temperature-sensitive Hydrogel, Based on Poly(styrene-alt-maleic anhydride) Copolymer
title_sort kinetic study of ibuprofen release from a ph- and temperature-sensitive hydrogel, based on poly(styrene-alt-maleic anhydride) copolymer
publisher Science Faculty of Chiang Mai University
publishDate 2019
url http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=7675
http://cmuir.cmu.ac.th/jspui/handle/6653943832/63849
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