Green Synthesis of Bis(indolyl)methanes Catalysed by Salicylic Acid
In this contribution, salicylic acid (SA) has been used to catalyze synthesis of a series of biologically relevant 3,3¢-bis(indolyl)methanes (BIMs) via the electrophilic substitution of indole derivatives on aldehyde compounds. The optimum catalyst loading was observed at 15 mol%. The procedure is s...
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| Main Authors: | , , |
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| Format: | บทความวารสาร |
| Language: | English |
| Published: |
Science Faculty of Chiang Mai University
2019
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| Online Access: | http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=8759 http://cmuir.cmu.ac.th/jspui/handle/6653943832/64035 |
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| Institution: | Chiang Mai University |
| Language: | English |
| Summary: | In this contribution, salicylic acid (SA) has been used to catalyze synthesis of a series of biologically relevant 3,3¢-bis(indolyl)methanes (BIMs) via the electrophilic substitution of indole derivatives on aldehyde compounds. The optimum catalyst loading was observed at 15 mol%. The procedure is simple and the expected bis-heterocyclic compounds were isolated in good to high yields. The present protocol provides the advantages of convenience, mild reaction conditions, eco-friendliness, energy-saving, and no use of hazardous solvents. |
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