Modification of Anti-cancer Co-crystal for Thymidylate Synthase Inhibition: Molecular Dynamics Study

• Main Authors: Nadia Hanim Sabri, Siti Nadiah Abd. Halim, Sharifuddin Md Zain, Vannajan Sanghiran Lee
• Format: บทความวารสาร
• Language: English
• Published: Science Faculty of Chiang Mai University 2019
• Online Access: http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=9522; http://cmuir.cmu.ac.th/jspui/handle/6653943832/64203
• Institution: Chiang Mai University

Raltitrexed (tomudex) is an alternative antifolate drug to 5-fluorouracil (5-FU) to inhibit thymidylate synthase (TS) by decreasing dihydrofolate reductase (DHFR) activity. The clinical trial shows the potential of raltitrexed towards TS inhibition can be enhanced by combining the raltiterexed with...