Modification of Anti-cancer Co-crystal for Thymidylate Synthase Inhibition: Molecular Dynamics Study
Raltitrexed (tomudex) is an alternative antifolate drug to 5-fluorouracil (5-FU) to inhibit thymidylate synthase (TS) by decreasing dihydrofolate reductase (DHFR) activity. The clinical trial shows the potential of raltitrexed towards TS inhibition can be enhanced by combining the raltiterexed with...
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| Main Authors: | , , , |
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| Format: | บทความวารสาร |
| Language: | English |
| Published: |
Science Faculty of Chiang Mai University
2019
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| Online Access: | http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=9522 http://cmuir.cmu.ac.th/jspui/handle/6653943832/64203 |
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| Institution: | Chiang Mai University |
| Language: | English |