Microwave Method for the Synthesis of Amantadine Hydrochloride
An easy and rapid method to prepare amantadine hydrochloride (1), which was used for the treatment of certain influenza infections type A and Parkinson’s disease was developed. In this work, we report a microwave method, which was effective in heating and saving solvents, for the synthesis of amant...
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Science Faculty of Chiang Mai University
2019
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| Online Access: | http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=9530 http://cmuir.cmu.ac.th/jspui/handle/6653943832/64217 |
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th-cmuir.6653943832-642172019-05-07T09:59:53Z Microwave Method for the Synthesis of Amantadine Hydrochloride Thinh Van Nguyen Hien Van Pham Duong Binh Vu Anh Tuan Dang Vu Khac Tran Chau Dinh Phan An easy and rapid method to prepare amantadine hydrochloride (1), which was used for the treatment of certain influenza infections type A and Parkinson’s disease was developed. In this work, we report a microwave method, which was effective in heating and saving solvents, for the synthesis of amantadine hydrochloride from adamantane by Ritter-type reaction via N-(1-adamantyl)acetamide in a two-step procedure with an improved overall yield 71%. The reaction conditions were investigated to increase the overall yield and to shorten the reaction time, reduce the use of toxic reagents, solvents, rendering it more effective and environment-friendly. 2019-05-07T09:59:53Z 2019-05-07T09:59:53Z 2018 บทความวารสาร 0125-2526 http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=9530 http://cmuir.cmu.ac.th/jspui/handle/6653943832/64217 Eng Science Faculty of Chiang Mai University |
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English |
| description |
An easy and rapid method to prepare amantadine hydrochloride (1), which was used for the treatment of certain influenza infections type A and Parkinson’s disease was developed. In this work, we report a microwave method, which was effective in heating and saving solvents, for the synthesis of amantadine hydrochloride from adamantane by Ritter-type reaction via N-(1-adamantyl)acetamide in a two-step procedure with an improved overall yield 71%. The reaction conditions were investigated to increase the overall yield and to shorten the reaction time, reduce the use of toxic reagents, solvents, rendering it more effective and environment-friendly. |
| format |
บทความวารสาร |
| author |
Thinh Van Nguyen Hien Van Pham Duong Binh Vu Anh Tuan Dang Vu Khac Tran Chau Dinh Phan |
| spellingShingle |
Thinh Van Nguyen Hien Van Pham Duong Binh Vu Anh Tuan Dang Vu Khac Tran Chau Dinh Phan Microwave Method for the Synthesis of Amantadine Hydrochloride |
| author_facet |
Thinh Van Nguyen Hien Van Pham Duong Binh Vu Anh Tuan Dang Vu Khac Tran Chau Dinh Phan |
| author_sort |
Thinh Van Nguyen |
| title |
Microwave Method for the Synthesis of Amantadine Hydrochloride |
| title_short |
Microwave Method for the Synthesis of Amantadine Hydrochloride |
| title_full |
Microwave Method for the Synthesis of Amantadine Hydrochloride |
| title_fullStr |
Microwave Method for the Synthesis of Amantadine Hydrochloride |
| title_full_unstemmed |
Microwave Method for the Synthesis of Amantadine Hydrochloride |
| title_sort |
microwave method for the synthesis of amantadine hydrochloride |
| publisher |
Science Faculty of Chiang Mai University |
| publishDate |
2019 |
| url |
http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=9530 http://cmuir.cmu.ac.th/jspui/handle/6653943832/64217 |
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1681426040485838848 |